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Blood, Heart and Circulation

Study points to possible treatment for a rare vascular disease

By Ziba Kashef Mice treated with P13K inhibitor (righti) no longer have vascular defects seen in HHT (left). In individuals with a rare genetic ...

A change of heart: Epigenetic basis of cardiac hypertrophy uncovered

The heart is an amazingly adaptable organ, responding to the needs of the organism throughout life, such as through periods of increased ...

Study finds risk of hemorrhage with combination of two common statins and stroke prevention drug

By Leslie Shepherd Two commonly prescribed statins appear to be associated with a higher risk of bleeding than others when combined with dabigatran, a drug often ... Full story

Scientists Successfully Create Blood from Skin Cells

Development could pave way for improved therapeutics for patients with immune disorders ... Full story

CyberKnife used to treat rare condition in pediatric patient

The CyberKnife, invented at Stanford, is being used to treat a young girl’s arteriovenous malformation, a deadly tangle of abnormal blood vessels. ... Full story

Heart disease, high blood pressure and diabetes may combine to worsen thinking skills

Research from the University of Glasgow shows that people who have a cardiometabolic disease, such as high blood pressure, diabetes or coronary heart disease (CHD), ... Full story

New therapeutic target for diseases caused by lack of oxygen

Recerca An international scientific team has developed a new small molecule –VH298- which can provoke a hypoxic response controlled from outside the cells, according to a ... Full story

Injectable Biologic Therapy Dramatically Reduces Triglycerides

Penn study finds first-of-its-kind therapy promising for patients with high triglycerides, cholesterol ... Full story

New peripheral artery disease guidelines emphasize medical therapy and structured exercise

•Patients with peripheral artery disease (PAD) should be on a program of guideline-directed medical therapy (including antiplatelet drugs that thin blood and statins to lower cholesterol) and should participate in a structured exercise program. •Restoring blood flow to the legs through vascular procedures is appropriate for many patients with severe symptoms due to PAD. •Eliminating exposure to all tobacco – including second-hand smoke – is highly recommended for patients with PAD. ... Full story

Activation of Two Genes Linked to Development of Atherosclerosis

Researchers at Brigham and Women’s Hospital have found two new potential drug targets for treating arterial diseases such as atherosclerosis. By using proteomics to screen a vast number of molecules, the researchers identified PARP9 and PARP14 – two members of the PARP family of proteins – as regulators of macrophage activation, which has been linked to arterial disease by systems biology. ... Full story

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