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Alzheimer’s

Marijuana compound may offer treatment for Alzheimer’s disease

University of South Florida preclinical study indicates ...

How Alzheimer’s Peptides Shut Down Cellular Powerhouses

Freiburg biochemists discover new mechanisms of the brain disease ...

Mayo Clinic study examines thoughts on predictive tests for Alzheimer’s

PHOENIX — A new Mayo Clinic study examines the question “what would you do if you knew you are predisposed to Alzheimer’s disease?” ... Full story

Brain Benefits from Weight Loss Following Bariatric Surgery

Researchers theorize procedure could reduce risk of Alzheimer’s in obese people ... Full story

Research on pomegranate drug to stem Alzheimer’s and Parkinson’s

Pomegranates Regular intake and regular consumption of pomegranate has many health benefits including prevention of neuro-inflammation related to dementia which slows down the progression of the disease. Fri, 22 Aug 2014 12:16:00 BST Dr Olumayokun Olajide’s research will now look to produce compound derivatives of punicalagin for a drug that would treat neuro-inflammation Dr Olumayokun Olajide ‌THE onset of Alzheimer’s disease can be slowed and some of its symptoms curbed by a natural compound that is found in pomegranate. Also, the painful inflammation that accompanies illnesses such as rheumatoid arthritis and Parkinson’s disease could be reduced, according to the findings of a two-year project headed by University of Huddersfield scientist Dr Olumayokun Olajide, who specialises in the anti-inflammatory properties of natural products. Now, a new phase of research can explore the development of drugs that will stem the development of dementias such as Alzheimer’s, which affects some 800,000 people in the UK, with 163,000 new cases a year being diagnosed. Globally, there are at least 44.4 million dementia sufferers, with the numbers expected to soar. The key breakthrough by Dr Olajide and his co-researchers is to demonstrate that punicalagin, which is a polyphenol – a form of chemical compound – found in pomegranate fruit, can inhibit inflammation in specialised brain cells known as micrologia. This inflammation leads to the destruction of more and more brain cells, making the condition of Alzheimer’s sufferers progressively worse. There is still no cure for the disease, but the punicalagin in pomegranate could prevent it or slow down its development. Dr Olumayokun Olajide Dr Olajide worked with co-researchers – including four PhD students – in the University of Huddersfield’s Department of Pharmacy (pictured left) and with scientists at the University of Freiburg in Germany. The team used brain cells isolated from rats in order to test their findings. Now the research is published in the latest edition of the journal Molecular Nutrition & Food Research and Dr Olajide will start to disseminate his findings at academic conferences. He is still working on the amounts of pomegranate that are required, in order to be effective. “But we do know that regular intake and regular consumption of pomegranate has a lot of health benefits – including prevention of neuro-inflammation related to dementia,” he says, recommending juice products that are 100 per cent pomegranate, meaning that approximately 3.4 per cent will be punicalagin, the compound that slows down the progression of dementia. Dr Olajide states that most of the anti-oxidant compounds are found in the outer skin of the pomegranate, not in the soft part of the fruit. And he adds that although this has yet to be scientifically evaluated, pomegranate will be useful in any condition for which inflammation – not just neuro-inflammation – is a factor, such as rheumatoid arthritis, Parkinson’s and cancer. The research continues and now Dr Olajide is collaborating with his University of Huddersfield colleague, the organic chemist Dr Karl Hemming. They will attempt to produce compound derivatives of punicalagin that could the basis of new, orally administered drugs that would treat neuro-inflammation. Dr Olajide has been a Senior Lecturer at the University of Huddersfield for four years. His academic career includes a post as a Humboldt Postdoctoral Research Fellow at the Centre for Drug Research at the University of Munich. His PhD was awarded from the University of Ibadan in his native Nigeria, after an investigation of the anti-inflammatory properties of natural products. He attributes this area of research to his upbringing. “African mothers normally treat sick children with natural substances such as herbs. My mum certainly used a lot of those substances. And then I went on to study pharmacology!” ... Full story

Investigational therapy focuses on slowing progression in mild to moderate Alzheimer’s

Houston Methodist’s Nantz National Alzheimer Center only Texas site to offer this study ... Full story

Human Brain Deficits of PKCe: Targeted for Alzheimer’s Disease Therapeutic and Diagnostic Trials

Today, researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) announced findings from a new study entitled, “PKCe Deficits in Alzheimer’s Disease Brains and Skin Fibroblasts.” ... Full story

DNA Methylation Involved in Alzheimer’s Disease

Boston, MA - A new study led by researchers at Brigham and Women's Hospital (BWH) and Rush University Medical Center, reveals how early changes in brain DNA methylation are involved in Alzheimer's disease. DNA methylation is a biochemical alteration of the building blocks of DNA and is one of the markers that indicate whether the DNA is open and biologically active in a given region of the human genome. ... Full story

Zebrafish help to unravel Alzheimer’s disease

​ New fundamental knowledge about the regulation of stem cells in the nerve tissue of zebrafish embryos results in surprising insights into neurodegenerative disease processes in the human brain. A new study by scientists at VIB and KU Leuven identifies the molecules responsible for this process. ... Full story

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