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Alzheimer's genetics point to new research direction

A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes ...

Study published showing a reversal of cognitive decline in Alzheimer's disease

Memory loss in Alzheimer's patients has been reversed with a tailor-made combination of diet, medication and and lifestyle changes, scientists claim. ...

VIB scientists announce unexpected breakthrough in Alzheimer’s disease research

Ground-breaking basic research reveals potential new therapeutic avenue ... Full story

New insight into role of amyloid beta in Alzheimer’s disease

Studies hint at therapeutic strategies against devastating disease ... Full story

New Alzheimer’s study aims to delay or prevent symptoms

The international trial co-managed by USC will test an inhibitor in people who show no symptoms of the disease ... Full story

Brain in a dish to learn more about Alzheimer’s disease

Researchers at the Institute have found a way to replicate one of the earliest changes in Alzheimer's disease in a dish. This means that it ... Full story

Alzheimer's researchers find clues to toxic forms of amyloid beta

A subtle change to the amyloid beta protein affects its aggregation behavior and stabilizes an intermediate form with enhanced toxicity ... Full story

Link between Alzheimer’s and gut bacteria?

Recent research with mice points to a link between the composition of gut flora and the development of Alzheimer’s disease. Researchers from KU Leuven and VIB have now joined a European research project that will investigate this link in greater detail and develop possible treatments based on their findings. ... Full story

The deadly toxin acrolein has a useful biological role

Scientists from RIKEN in Japan have discovered that acrolein—a toxic substance produced in cells during times of oxidative stress—in fact may play a role in preventing the process of fibrillation, an abnormal clumping of peptides that has been associated with Alzheimer's disease and other neural diseases. The key to this new role is a chemical process known as 4+4 cycloaddition, where two molecules with "backbones" made up of four-atom chains come together to form a ring-like structure with eight atoms. The group found that in some circumstances, acrolein can combine with a class of molecules called polyamines, which themselves are important biological players, to make substances that can prevent the fibrillation of Aβ40 peptides ... Full story

Roadmap for biomarker research on Alzheimer’s disease should lead to better results

Biomarkers could revolutionise the early detection of and therapy for Alzheimer’s disease. However, experts attending the Congress of the European Academy of Neurology (EAN) in Copenhagen criticized that the big breakthroughs are slow in coming because of a lack of priorities in research. A roadmap should help to push along advances in this area. ... Full story

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