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Uncovering a new principle in chemotherapy resistance in breast cancer

A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair ...

Emory, Metaclipse Therapeutics receive NIH grant to develop breast cancer vaccine

A research team from Emory University and Metaclipse Therapeutics Corp. is developing a new cancer vaccine immunotherapy targeting triple-negative breast cancer (TNBC). ...

Penn Preclinical Study Outlines Cardiovascular Side Effects of Breast Cancer Drug

PHILADELPHIA – A receptor protein that is the target of the breast cancer drug trastuzumab (Herceptin) is needed for proper heart blood-vessel development, reported researchers ... Full story

Exercise Improves Memory in Breast Cancer Survivors

Self-reported memory problems in survivors linked to high stress regardless of treatment ... Full story

Hops extract studied to prevent breast cancer

An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the UIC/NIH Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago. ... Full story

The importance of keeping silent... in breast cancer cells

Researchers at the Centre for Genomic Regulation describe a repression mechanism active in hormone-dependent breast cancer cells for the first time. The repression complex of these ... Full story

VICC Leads Study on High Breast Cancer Incidence and Mortality Rates in African-American Women

A cancer research consortium headed by investigators at Vanderbilt-Ingram Cancer Center (VICC) and two other institutions, today received $12 million in federal funding to help determine why African-American women die at a higher rate and have more aggressive breast cancer than white women. The grant, which was awarded by the National Cancer Institute (NCI), part of the National Institutes of Health, is based on the premise that having a better understanding of the biology–and, in particular, the genetics–of breast cancer in African-American women will lead to better prevention and treatment. ... Full story

Misaligned chromosomes give breast cancer cells a selection advantage

If chromosomes are distributed unevenly during cell division, this has a negative effect on the survival of daughter cells. However, in many cancer types, misaligned chromosomes are associated with a negative prognosis, meaning that they appear to benefit the cancer. Scientists at DKFZ have conducted trials with mice to investigate the effect of unevenly misaligned chromosomes on breast cancer. When the scientists triggered aberrant distribution of chromosomes in the mammary gland cells of mice, this delayed the development of breast cancer. However, the developing tumors appeared to have a selection advantage: they continued to grow even when the growth-promoting cancer gene had been switched off. ... Full story

Gene Mutation “Hotspots” Linked to Better Breast Cancer Outcomes

Genetic phenomenon associated with low tumor invasiveness and longer patient survival could inform prognosis and help identify patients who would best respond to immunotherapy and other treatments ... Full story

Cancer drug designed at Bath shows continuing clinical impact

New clinical data were revealed at the American Society for Clinical Oncology (ASCO) in Chicago last week, the world’s largest cancer congress, for Irosustat, a drug pioneered at the University of Bath that could prolong the lives of women with breast cancer. ... Full story

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