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Breast cancer replicates brain development process

New research led by a scientist at the University of York reveals that a process that forms a key element in the ...

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell

WEST LAFAYETTE, Ind. - Purdue University researchers have developed a way to detect and measure cancer levels in a living cell by ...

First genetic link discovered to difficult-to-diagnose breast cancer sub-type

Scientists have identified the first genetic variant specifically associated with the risk of a difficult-to-diagnose cancer sub-type accounting for around 10-15 per cent of all breast cancer cases. ... Full story

Proteins conspire to make breast cancer cells resistant to drug treatment

by Susan Gammon, Ph.D. - Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) provide compelling and conclusive evidence that antiestrogen resistance in breast cancer cells requires the interaction between proteins called BCAR1 and BCAR3. In the study, published in the Journal of Biological Chemistry, the researchers also identified a signaling pathway that is crucial for drug resistance mediated by this protein complex. ... Full story

New Blood-based Biomarker May Predict Recurrence of Breast Cancer and Treatment Response

PHILADELPHIA — A newly developed, noninvasive blood-based assay, cMethDNA, is highly sensitive and specific in detecting breast cancer recurrence early, and shows promise as a viable tool in predicting treatment outcome, according to data published in Cancer Research, a journal of the American Association for Cancer Research. ... Full story

Study in mice shows that an aggressive type of breast cancer is linked to an inflammatory protein

Aberrant expression of an inflammatory protein, nitric oxide synthase 2 (NOS2), may enhance the progression and metastasis of an aggressive and less common form of breast cancer, known as the estrogen receptor-negative type of disease. ... Full story

Promising drug doubles positive effect in hormone-receptor–positive breast cancer

By Shaun Mason - Breast cancer researchers from the Revlon/UCLA Women's Cancer Research Program at UCLA's Jonsson Comprehensive Cancer Center announced final clinical trial results this week that showed the amount of time patients were on treatment without their cancer worsening (called "progression-free survival") was effectively doubled in women with advanced breast cancer who took the experimental drug palbociclib. ... Full story

Mayo Clinic Shares Lessons Learned from Genomics Clinic for Sequencing-based Cancer Care and Diagnostics

ROCHESTER, Minn. — It has been 1.5 years since Mayo Clinic opened the world’s first integrated multidisciplinary genomics service, the Individualized Medicine Clinic, which uses genomics and next-generation sequencing technologies to personalize treatments for patients with advanced cancer and complex diagnoses. In a special issue of the American Journal of Medical Genetics Part C, “Implementation of Genomic Medicine,” developers of the Individualized Medicine Clinic report the clinic’s structure and share lessons learned in everything from efficacy of genomics in patient care to struggles with insurance reimbursement and ethical dilemmas. ... Full story

Western University study unlocking secrets of breast tissue

A unique population of microbes in the female breast may lay the groundwork for understanding how this bacterial community contributes to health and disease, according to a new study out of Western University. The study titled "Microbiota of human breast tissue," is now published online, in advance of the May issue of Applied and Environmental Microbiology. ... Full story

Scientists reveal potential link between brain development and breast cancer gene

LA JOLLA—Scientists at the Salk Institute have uncovered details into a surprising—and crucial—link between brain development and a gene whose mutation is tied to breast and ovarian cancer. ... Full story

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