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Researchers identify origin of chromosomal oddity in some cancer cells

Surveys of the genomic terrain of cancer have turned up a curious phenomenon in some tumor cells: a massive rearrangement of DNA ...

Nivolumab Treatment in Melanoma Patients has Manageable Safety Profile, Additional Immunomodulatory Agents Do Not Affect Response Rates, Say Moffitt Cancer Center Researchers

TAMPA, Fla. – The monoclonal antibody nivolumab has shown promise as a therapeutic agent, particularly by improving the survival rates of melanoma patients. Jeffrey S. Weber, M.D., Ph.D., director of the Donald A. Adam Comprehensive Melanoma Research Center at Moffitt Cancer Center will be presenting data from a retrospective analysis of the safety of nivolumab in 4 ongoing phase I-III studies in melanoma patients at the 2015 American Society of Clinical Oncology Annual Meeting in Chicago. ... Full story

JAK2 Inhibitor Ruxolitinib has Minimal Toxicity, Promising Efficacy in Chronic Myelomonocytic Leukemia Patients, Say Moffitt Cancer Center Researchers

TAMPA, Fla. – Chronic myelomonocytic leukemia (CMML) is a rare type of myelodysplastic, myeloproliferative neoplasm characterized by increased numbers of peripheral monocytes and less than 20 percent blasts. ... Full story

Australian GPs lead the way with early referrals for suspected cancer patients

Doctors in Victoria and New South Wales are more likely to immediately refer people with possible cancer for tests or to a specialist than those in comparable countries, new research published in BMJ Open has revealed. ... Full story

Pinpointing natural cancer drug's true origins brings sustainable production a step closer

ANN ARBOR—For decades, scientists have known that ET-743, a compound extracted from a marine invertebrate called a mangrove tunicate, can kill cancer cells. The drug has been approved for use in patients in Europe and is in clinical trials in the U.S. ... Full story

Diagnosing cancer with help from bacteria

Engineered probiotics can detect tumors in the liver. ... Full story

Tumor surroundings are shown to affect progression of different cancer subtypes

Treatments may need to be tailored not just to specific cancer types but also to factors distinguishing the environments in which they develop ... Full story

Researchers discover molecular approach to promote cancer cell death

The protein Bcl-2 is a known target for cancer treatment since it allows cancer cells to evade cell death via apoptosis. ... Full story

The devastating condition that can cause cancer in children

Doctoral candidate Lindiwe Lamola has had a grudge against cancer since it caused the death of her much-loved grandmother. She is channeling her energies into examining a rare genetic syndrome that puts people at risk of developing cancer in childhood. ... Full story

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