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Digestive System

Researchers Make Progress Engineering Digestive System Tissues

WINSTON-SALEM, N.C. – New proof-of-concept research at Wake Forest Institute for Regenerative Medicine suggests the potential for engineering replacement intestine tissue ...

Method of delivery affects stabilization of gut microbiota

Bacteria colonize the intestines at the time of birth. But the composition of the gut microbiota is affected by the method of ...

Starved T cells allow hepatitis B to silently infect liver

Hepatitis B stimulates processes that deprive the body’s immune cells of key nutrients that they need to function, finds new UCL-led research funded by the Medical Research Council and Wellcome Trust. ... Full story

Underappreciated Cause of Bowel Obstruction Should Be Included in Surgical Assessments

Each year, more than 10 million Americans seek medical attention, often in emergency situations, for symptoms of intestinal blockages. Researchers at the University California, San Diego School of Medicine have identified an abnormal form of small bowel twisting (or volvulus) that may cause these painful obstructions. In contrast to other causes of bowel obstruction that are treated with bowel rest, these require immediate surgical care. ... Full story

Nanoparticles in Consumer Products Can Significantly Alter Normal Gut Microbiome

New Rochelle, NY — Exposure of a model human colon to metal oxide nanoparticles, at levels that could be present in foods, consumer goods, or treated drinking water, led to multiple, measurable differences in the normal microbial community that inhabits the human gut. ... Full story

Weill Cornell Investigators Discover a New Pathway that Prevents Chronic Inflammation in the Gut

Investigators Show How Immune Cells are "Educated" Not to Attack Beneficial Bacteria ... Full story

Cirrhosis deaths drop 41 percent from 2002 to 2012

A new study by UNC researchers has found dramatic improvements in the care of patients with cirrhosis and liver failure and recommends improved treatment strategies for patients with cirrhosis and concurrent bacterial infections. ... Full story

Microbes Help Produce Serotonin in Gut

Although serotonin is well known as a brain neurotransmitter, it is estimated that 90 percent of the body's serotonin is made in the digestive tract. In fact, altered levels of this peripheral serotonin have been linked to diseases such as irritable bowel syndrome, cardiovascular disease, and osteoporosis. New research at Caltech, published in the April 9 issue of the journal Cell, shows that certain bacteria in the gut are important for the production of peripheral serotonin. ... Full story

Mouth, as well as gut, could hold key to liver disease flare-ups

In a recent study, Virginia Commonwealth University School of Medicine researchers predicted which cirrhosis patients would suffer inflammations and require hospitalization by analyzing their saliva, revealing a new target for research into a disease that accounts for more than 30,000 deaths in the United States each year. ... Full story

To fight nasty digestive bugs, U-M scientists set out to build a better gut – using stem cells

New $6.4M federal grant support will fuel the development of “guts in a dish” to study interaction between cells & microbes in both health and disease ... Full story

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