01:32pm Monday 27 February 2017

Intensive training for aphasia: even older patients can improve



The study was published in Brain and Language.After six weeks of intensive and specific language therapy, seniors with aphasia demonstrated better performance at naming objects along with better cognitive potential. “The evidence collected in this functional neuroimaging study shows that language therapy stimulates the brain to use alternate circuits. These new circuits remain active after therapy and can help the person recover additional words. Performance was equivalent six months after the study, and family members told us that they could still see improvements at this point,” explained Dr. Ansaldo.

This training not only stimulates the circuits that deal with language but also integrates another major brain system called the default mode network. This network is characterized by activity when the brain is “on standby” and not focused on performing a particular task. For the first time, this study describes the activity of this network in people with aphasia, and points out irregularities associated with this language impairment. Abnormal functioning in the default network has been associated with cognitive deficits, such as attention or episodic memory disorders. The study showed that following speech-therapy, connectivity in the default mode in aphasic subjects reached a similar level to that of the healthy control subjects after therapy.

“The results of this study are encouraging regarding the aging brain’s potential to recover. Thus, seniors who have had aphasia for many years are often no longer receiving treatment for their condition. We have shown that language therapy has a positive impact even long time after stroke, and not only on language but also on general cognition, as shown by the positive changes in the default network. My hope is that these findings will change clinical attitudes towards seniors who suffer from language disorders, by providing intensive, specific and focused stimulation for these patients. This therapy leads to very promising outcomes, even long after diagnosis,” concluded Dr. Ansaldo.

Research summary
Previous research on participants with aphasia has mainly been based on standard functional neuroimaging analysis. Recent studies have shown that functional connectivity analysis can detect compensatory activity, not revealed by standard analysis. Little is known, however, about the default-mode network in aphasia. In the current study, we studied changes in the default-mode network in subjects with aphasia who underwent semantic feature analysis therapy. We studied nine participants with chronic aphasia and compared them to ten control participants. For the first time, we identified the default-mode network using spatial independent component analysis, in participants with aphasia. Intensive therapy improved integration in the posterior areas of the default-mode network concurrent with language improvement. Correlations between integration and improvement did not reach significance, but the trend suggests that pre-therapy integration of the default-mode network may predict therapy outcomes. Functional connectivity allows a better understanding of the impact of semantic feature analysis in aphasia.

About the author
Dr. Ana Inés Ansaldo, PhD, Biomedical Sciences – Speech-Language Pathology Researcher at the Research Centre of the IUGM Director of the Brain Plasticity, Communication and Aging Laboratory Director of Education at the Institut universitaire de gériatrie de Montréal (IUGM) Professor in the School of Speech-Language Pathology and Audiology, Faculty of Medicine, Université de Montréal

Marcotte K, Perlbarg V, Marrelec G, Benali H, Ansaldo AI. “Default-mode network functional connectivity in aphasia: Therapy-induced neuroplasticity”, Brain and Language Journal, December 26, 2012.

Overview of the IUGM
The IUGM consists of 452 short-and long-terms beds and an ambulatory care centre that includes one of the rare chronic pain management clinics for the elderly in the world. It is a leader in clinical practice, specialized care, health promotion and knowledge development in the field of aging and senior health in Quebec. The IUGM consists of 1300 employees, physicians, researchers and volunteers, all specialized in senior care and services. Our Research Centre is recognized as the largest in the French-speaking community. Each year, the IUGM welcomes hundreds of students, trainees and researchers studying in the field of aging and seniors’ health issues.

For Media, a complete version of the study is available on request.

Source:              Institut universitaire de gériatrie de Montréal

Geneviève Desrosiers or Frédérique Laurier
Communications and Public Affairs
514 340-2800, ext. 3298 or 3554

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