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Immune System

Late-stage sepsis suppresses immune system

By Jim Dryden - Patients who die from sepsis are likely to have had suppressed immune systems that left them unable to fight infections, researchers at Washington University School of Medicine in St. Louis have shown.
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Researchers discover novel anti-viral immune pathway in the mosquito

BLACKSBURG, Va. – As mosquito-borne viral diseases like West Nile fever, dengue fever, and chikungunya fever spread rapidly around the globe, scientists at Virginia Tech are working to understand the mosquito's immune system and how the viral pathogens that cause these diseases are able to overcome it to be transmitted to human and animal hosts....
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Diseases and sex

The cocktail maintaining immune gene variation ...
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UGA scientists ‘hijack’ bacterial immune system

Discovery reveals new possibility for gene silencing in bacteria and other organisms...
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Who’s the boss? Research shows cells influence their own destiny

In a major shake-up of scientists’ understanding of what determines the fate of cells, researchers at the Walter and Eliza Hall Institute have shown that cells have some control over their own destiny....
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New findings about the prion protein and its interaction with the immune system

Scrapie is a neurodegenerative disease which can function as a model for other diseases caused by an accumulation of proteins resulting in tissue malformations (proteinpathies), such as Alzheimer's and Parkinson's disease. ...
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Discovered the existence of neutrophils in the spleen

The article has been published on-line at the prestigious magazine Nature Immunology and will be the front cover of the printed issue of next February....
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Targeted blocking of necroptosis prevents fatal condition septic shock

Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. In sepsis, acute inflammation is attended by low blood pressure and blood clots, causing the organs to stop working. Only recently, the Brazilian football legend Socrates, died of the consequences of this condition. In a new study in the top journal Immunity, Peter Vandenabeele and colleagues of VIB-UGent described how blocking a particular form of cell death (necroptosis) fully protects mice against this fatal inflammation....
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New Synthetic Molecules Treat Autoimmune Disease in Mice

A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn’s and rheumatoid arthritis, the immune system mistakenly attacks the body’s tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body’s players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine....
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Scientists Engineer Mosquito Immune System to Block Malaria

Researchers at the Johns Hopkins Malaria Research Institute demonstrated for the first time that the Anopheles mosquito’s innate immune system could be genetically engineered to block the transmission of the malaria-causing parasite to humans. ...
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