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How meningitis bacteria ‘slip under the radar’

Scientists have discovered a natural temperature sensor in one of the bacteria that cause meningitis and blood poisoning, which allows them to evade the body’s immune response leading to life-threatening infections.

The study, funded by the Medical Research Council (MRC) and the Wellcome Trust, found that increasing the temperature causes the bacteria to make more capsule – a protective layer that surrounds the bacterium like an ‘invisibility cloak’, helping it to evade detection by the immune system.

The research, published in Nature, suggests that people may be more susceptible to infection by the bacteria when they have a fever and could explain why outbreaks of flu (which causes fever) are often followed by an increase in cases of sepsis and meningitis. The findings also shed light on how these bacteria evolved into a dangerous killer and might help scientists develop new vaccines against the bacteria in future.

Meningococcus bacteria are found naturally in up to a third of the population. In most cases they are completely harmless, but in certain circumstances they can invade the bloodstream and brain, causing serious ‘meningococcal’ illness. One of these illnesses, sepsis (more commonly known as blood poisoning), is extremely serious and is fatal in around one in 10 cases. Meningococcal illness is also the leading infectious cause of death in early childhood.

Understanding bacterial defence mechanisms has been important in developing existing vaccines, so researchers at the University of Oxford and Imperial College London wanted to investigate this mechanism in meningococcus.

They studied the bacteria in the laboratory to see how they behave at different temperatures and they found that capsule production is controlled by tiny temperature sensors in the bacteria’s genetic code. A rising temperature acts as a ‘danger signal’ to the bacteria causing them to produce more protective capsule and other molecules essential for resistance against an immune response.

This suggests that the bacteria can evolve over time to survive more hostile attacks from the body. Those that do survive will be conditioned to respond to the body’s heat, making them more virulent and allowing them to move to warmer areas below the surface of the throat, where they can cause infection.

Professor Christoph Tang, who led the research at the Sir William Dunn School of Pathology, University of Oxford, said:

“These infections are extremely dangerous to vulnerable groups, particularly young children, and can cause blindness, brain damage and limb loss. We hope that this research will help us understand how the bacteria cause disease, and might one day help us prevent serious infection.”

Professor Doreen Cantrell, Chair of the MRC Infections and Immunity Board, which funded the study, said:

“Understanding how bacteria work and interact with the immune system is critical for developing new treatment strategies for infectious diseases. This research gives us some fascinating new insights into how the bacteria that cause meningitis evolved into such a dangerous killer and could help inform future strategies to prevent this disease.”

Further information

 

Contact the MRC press office on 0207 239 2345 (out of hours: 07818 428 297), email press.office@headoffice.mrc.ac.uk

 

The paper, entitled ‘Temperature triggers immune evasion by Neisseria meningitidis’, by Loh E, et al, is published in Nature (DOI: 10.1038/nature12616).

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