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Medical Breakthroughs

New nanodevice defeats drug resistance

Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs. ...

Johns Hopkins Researchers Identify Key to Tuberculosis Resistance

Mouse studies may lead to development of human therapies ...

New views of enzyme structures offer insights into metabolism of cholesterol, other lipids

ANN ARBOR—With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to metabolize excess lipids, including cholesterol. ... Full story

Drug Research and Development More Efficient Than Expected

Despite ever increasing regulation in drug approval and the rising costs of research, drug research and development (R&D) remains unexpectedly efficient. This shows a study conducted by the European Center of Pharmaceutical Medicine (ECPM) at the University of Basel. The results have been published in the journal Nature Reviews/Drug Discovery. ... Full story

New Compounds Protect Nervous System From the Structural Damage Characteristic of Multiple Sclerosis

Pharmacological Agents Hold Promise for Several Neurodegenerative Disorders ... Full story

Synthetic biology breakthrough leads to cheaper statin production

University of Manchester researchers, together with industrial partner DSM, have developed a single-step fermentative method for the production of leading cholesterol-lowering drug, pravastatin, which will facilitate industrial-scale statin drug production. ... Full story

Scientists Discover Robust Evidence That Chronic Fatigue Syndrome Is a Biological Illness

Immune Signatures in Blood Point to Distinct Disease Stages, Open Door to Better Diagnosis and Treatment ... Full story

Small Molecule Helps Get Stem Cells to Sites of Disease and Damage

Bioengineers from Brigham and Women’s Hospital (BWH) with collaborators at the pharmaceutical company Sanofi have identified small molecules that can be used to program stem cells to home in on sites of damage, disease and inflammation. ... Full story

Breakthrough in understanding how cancer cells metastasize

Montreal Neurological Institute scientists discover a new mechanism driving spread of cancer ... Full story

Stellate cells in the liver control regeneration and fibrosis

by Koh - Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty in Mannheim at Heidelberg University are searching for new approaches to prevent liver fibrosis. They have identified a surface molecule on special liver cells called stellate cells as a potential target for interfering with this process. When the researchers turned off the receptor, this led to reduced liver fibrosis and improved regeneration of hepatic cells. ... Full story

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