Chris Power and a team of researchers in the Faculty of Medicine & Dentistry recently published their findings in the peer-reviewed publication, The Journal of Immunology.
“We found there is a compound in saffron, known as crocin, which exerts a protective effect in brain cell cultures and other models of MS. It prevented damage to cells that make myelin in the brain,” Power said. “Myelin is insulation around nerves, and multiple sclerosis is characterized by inflamed brain cells that have lost this protective insulation, which ultimately leads to neurodegeneration.”
Power noted they are not close to a clinical trial stage yet, but the finding is still exciting. It has been known in the research community for years that crocin protected neurons in certain situations but Power and his team wanted to delve further into this area.
His team discovered that inflammation and a specific type of cell stress are closely linked and lead to neurodegeneration and inflammation, which cause cells to lose their protective coating, a process known as demyelination. In experiments conducted by Power and his colleagues, the use of crocin suppressed both inflammation and this specific type of cell stress, resulting in decreased neurological impairment in lab models and cell cultures with multiple sclerosis.
“There are still many questions to be answered about how crocin exerts these neuroprotective effects, but this research highlights a potential treatment role for crocin in diseases involving chronic neuroinflammation—something that had not been recognized until now,” says Power.
He explained the research demonstrates a new mechanism in multiple sclerosis, provides new potential drug targets in the future and helps explain why physicians see inflammation in multiple sclerosis.
The team’s research also revealed that this specific type of cell stress, called the unfolded protein response, may be caused by an ancient virus that was introduced into the DNA of early humans. This particular cell stress is found at high levels in MS brain lesions.
“We all have this ancient virus in our DNA, but for some reason it is excessively turned on in MS,” says Power. “We are doing more research investigating this link.”
Power has been investigating this specific area for six to seven years. His research is funded by the MS Society of Canada and the federal government through the Canada Research Chair program.