Clinical physical therapy is a widely used treatment approach to help restore the motor function of patients following neurological injuries. Unfortunately many of the specific treatments used in the clinic only restore function to a specific task, and not to a wide range of everyday activities. This is also true in animal research where stand training only leads to better standing, step training only leads to better stepping, and so forth.
Researchers at Georgetown University Medical Center have investigated the effects of training rats with spinal cord injuries on a robotic device (Rodent Robotic Motor Performance System, Robomedica Inc, Irvine, Calif.) that precisely guides the hindlimbs through a training pattern. The training pattern chosen for this research was the mean pattern recorded before the rats were injured. The results were presented during a nanosymposium at the 39th annual meeting of the Society of Neuroscience.
For four weeks, half of the rats received daily training on the robotic trainer and half did not. At the end of each training week, and two weeks after completion of the full training program, walking performance of all animals was measured. After four weeks of training, trained animals had shorter stride lengths than the non-trained animals both within the device as well as overground.
“Our results show that increasing activity using a precise and repeatable physiologically relevant training pattern can modify overground locomotion,” says Nathan D. Neckel, PhD, a post-doctoral fellow in the department of neuroscience. “These findings suggest that more accurate and precise exercises in the human physical therapy clinic may lead to the restoration of function in everyday tasks.”
The study was funded by grants from the National Institute of Child Health and Human Development. The authors report no related financial interests.
About Georgetown University Medical Center
Georgetown University Medical Center is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through Georgetown’s affiliation with MedStar Health). GUMC’s mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis – or “care of the whole person.” The Medical Center includes the School of Medicine and the School of Nursing and Health Studies, both nationally ranked, the world-renowned Lombardi Comprehensive Cancer Center and the Biomedical Graduate Research Organization (BGRO), home to 60 percent of the university’s sponsored research funding.
Karen Mallet (media only)