Best CBD Oil For Nausea – Top 4 Fast-Acting Choices

Advertiser Disclosure

All products picked below meet our established standards. Health Canal joins affiliate program of brands like: Spruce CBD, Talkspace, GundryMD… We will earn a small commission from your purchase. Learn more about how we earn revenue by reading our advertise disclaimer

Updated on - Written by
Medically reviewed by Kimberly Langdon, MD

Best CBD Oil For Nausea

Nausea is an uneasiness in the stomach that usually occurs before vomiting. It’s an awful, queasy feeling that is annoying and unpleasant and may be referred to as an “upset stomach” or “motion sickness.” It can make you want to curl up in a corner and hide from the world. It can lead to uncontrollable bouts of vomiting or leave you feeling dizzy and giddy. Examples of nausea include that feeling you get from motion sickness from a car or airplane, taking pills on an empty stomach, eating too much or too little, or overindulging in alcohol.

Nausea is associated with decreased gastric motility and increased tone in the small intestine. Also, there is reverse peristalsis in the small intestine associated with the feeling of nausea. Peristalsis is a series of wave-like motions that move food down the digestive tract. Reverse peristalsis would cause food to move out of the digestive system through vomitings, such as food poisoning or motion sickness.

Top 5 Best CBD oil for Nausea (September. 2021)

Does CBD Help With Nausea

There is insurmountable evidence[1] that manipulation of the endocannabinoid system may beneficially affect nausea and vomiting. According to the British Journal of Pharmacology[1] cannabinoids, specifically, cannabidiol (CBD), may be an effective treatment for nausea and vomiting induced by chemotherapy or other medical therapy.

Cannabinoids were more effective[2] at decreasing nausea than several antiemetic medications tried on selected patients in a systematic literature review. The marijuana plant has been used for centuries[3] to treat nausea and vomiting, so it seems only natural to turn to CBD oil as a potential remedy for this symptom. Tetrahydrocannabinol (THC) proved useful in treating nausea and vomiting initially before CBD being considered, but its potential for psychoactive effects makes it less desirable for nausea treatment.  

While there is limited research on CBD and nausea, animal research indicates that CBD might affect nausea by interacting with serotonin receptors[1]. Serotonin is responsible for the urge to push food out of the body to rid itself of noxious substances or stimuli. Yes, stimuli. Sights and sounds, as well as anxiety-producing situations, can all create nausea. And serotonin is involved in all of these reactions. 

Editor’s Choice

Take Spruce CBD

Spruce CBD

Why is it better?

  • Third-party testing
  • Unique strain of hemp
  • Family run business
  • No pesticides
  • Full-spectrum

Free Shipping and 15% Off Coupon: HEALTHCANAL

Read Review Details

The Lineup At A Glance

Best affordability

  • Organic hemp
  • Product guarantee
  • Affordable

Free Shipping and 15% Off Coupon: “HEALTHCANAL”

Best Organic

  • THC free, Broad-spectrum
  • Gluten-free
  • High-quality Colorado hemp

Check Price

20% Off Coupon: “HEALTHCANAL”

Best Vegetarian

  • Gluten-free
  • Non-GMO
  • Vegetarian
  • Contains CBDA

15% Off Coupon: “HEALTHCANAL”

Best Variety

  • Wide variety of potencies
  • High-quality Kentucky hemp
  • Organic hemp

25% Off Coupon: “HEALTHCANAL”

Top 5 Best CBD Oil for Nausea 2021

Spruce CBD

Take Spruce CBD

Spruce is a family-run CBD brand that offers high-quality, lab-tested, full-spectrum CBD oil made from one of the finest, oldest hemp strains in the United States.

  • Third-party tested
  • Unique strain of organic hemp
  • Family-run business
  • No pesticides
  • Full-spectrum
  • Limited product range
  • Costs more than average

Free Shipping and 15% Off Coupon: HEALTHCANAL


Established in 2018, Spruce is a CBD brand based in Raleigh, North Carolina. The company prides itself on making American-made CBD products.

Spruce stands out from the competition in several ways. For instance, it’s a family-run business, which is unusual in the CBD industry.

Its CBD is sourced from a time-tested strain of hemp that’s been cultivated in the United States for over two hundred years. The CBD oil is harvested from organically grown hemp from farms in Kentucky and North Carolina.

Spruce is also unique for using a moonshine (alcohol) extraction method to isolate a CBD-rich extract from hemp. Although most CBD companies use CO2 extraction, alcohol extraction is just as safe and effective. 

Spruce’s CBD oil is made with a lab-tested hemp extract, and it provides all of the cannabinoids, terpenes, and other beneficial compounds found in the plant. The THC content is <0.3%.

It has a pleasing peppermint taste and comes in 30 ml bottles with two CBD potencies: 25 mg of CBD per ml (750 mg total) and 80 mg of CBD per ml (2400 mg total).

Like all reputable CBD companies, Spruce provides comprehensive third-party test reports to confirm its CBD oils’ safety and potency. Besides working well on adults, Spruce CBD is also safe for kids, which makes it one of the most popular choice on the market.


CBDPure CBD Oil_1

CBDpure hosts a wide range of products made from lab tested hemp at an affordable price.

  • Organic hemp
  • Product guarantee
  • Affordable
  • Limited potencies

Free Shipping and 15% Off Coupon: “HEALTHCANAL”


From soil to oil, this hemp is a lab- tested and has a Certificate of Analysis that is downloadable at any location. The third-party lab testing guarantees that the best CBD oils produce quality CBD at a price you can afford. If prices are still too steep, they offer coupons you can use at check-out.

The company offers a 100% money-back guarantee if you return the products within a 90– day time-frame if you are not satisfied.

Their line of hemp oil products is grown without pesticides or herbicides guaranteeing you a wholesome source of the best CBD possible. 

The CBD products are made from hemp oil that contains a variety of cannabinoids, terpenes, and flavonoids extracted from the whole plant. It has less than 0.3% THC.

Joy Organics

Joy Organics CBD Oil

Joy Organics specializes in broad-spectrum CBD products, containing all of the beneficial components of hemp except THC. If you want to maximize CBD’s beneficial impact while avoiding THC, this brand is a great choice.

  • THC free, broad-spectrum
  • Gluten-free
  • High-quality Colorado hemp
  • Low levels of minor cannabinoids

Check Price

20% Off Coupon: “HEALTHCANAL”


Joy Organics’ products offer a high level of bioavailability with its nanotechnology generated CBD hemp oil. Nanotechnology allows the cannabinoid molecule to be broken down into a smaller size easier to absorb. While most CBD oil has between 150 and 500-nanometer particles, Joy Organics CBD oil products contain just 25-60.

The company uses a proprietary hemp extraction method that produces 112 minor cannabinoids but remains THC-free. It is a broad-spectrum oil that contains all the plant’s terpenes, cannabinoids, and flavonoids without the THC. 

Using CBD oil extracted from hemp grown in Colorado, Joy Organics produces some of the best CBD products on the market that are also gluten-free.

All products are subjected to in-house and lab-tested analysis producing Certificates of Analysis and a Certificate of Quality Assurance and remain free of harsh chemicals and metals.

Plus CBD

Plus CBD Oil-1

The company provides a wide range of vegetarian CBD products that are gluten-free and contain the minor cannabinoid, CBDA.

  • Gluten-free
  • Non-GMO
  • Vegetarian
  • Contains CBDA
  • Limited potencies to choose from

15% Off Coupon: “HEALTHCANAL”


PlusCBD products are full-spectrum products that also contain the cannabinoid CBDA. CBDA is known for its anti-inflammatory properties. CBDA is the raw, unheated version of CBD. In a study in rats, CBDA was a thousand times more potent than CBD[4] in binding to a specific serotonin receptor linked to anti-nausea and anti-anxiety effects when administered alongside low-doses of the traditional anti-nausea drug for chemotherapy patients, ondansetron. CBDA may be more desirable as a treatment for nausea and upset stomachs than using CBD oil.

CBD products include softgels, gummies, drops, sprays, lotions, creams, balms, and roll-ons. The wide variety of products leave a lot of the best choices for your CBD therapy. Sprays and drops may work better for an upset stomach, although taking the softgels with food may help. There are no up-to-date studies on the effects of topical CBD on an upset stomach or nausea caused by vomiting.

All products come from agricultural hemp and industrially grown hemp, thus guaranteeing the best CBD possible. Industrially grown hemp is used to manufacture rope, fuel, and textiles.

 A third-party lab carries out an analysis of the contents of products.



This innovative company, which started in 2015, hosts a wide variety of products that it sells nationally and internationally.

  • Wide variety of potencies
  • High-quality Kentucky hemp
  • Organic hemp

  • Important information not readily available
  • Returns not convenient

25% Off Coupon: “HEALTHCANAL”


CBDfx extracts its oils from hemp grown in Europe or Kentucky, where it is then shipped to southern California for further processing.

 CBDfx uses organic farming techniques and CO2 extraction to guarantee the most refined CBD oils it can produce. CO2 is widely considered the safest option for the extraction of hemp.

CBDfx manufactures full-spectrum oil. Thus, you are guaranteed the entourage effect that enhances the beneficial functions of CBD. Full-spectrum means you have the advantage of the terpenes, flavonoids, and cannabinoids, including CBG and CBN. Also, it has MCT oil in it for added nutrition. THC is at a compliance level of less than 0.3%.

 The product line is widely diverse, from those supplements made for pets’ use to those for the use of the rest of us like tinctures, oils, drinkable shots, sublingual strips in fun flavors, and capsules. CBD treatment can be fun and full of variety.

 A third-party lab analyzes contents and a Certificate of Analysis is available.

What Causes Nausea? Other Potential Reasons

Dealing with nausea can be annoying. There are many things that can cause nausea. Some people that have experienced the effects of nausea are particularly sensitive to motion sickness, food poisoning, medications, or the effects of certain medical conditions or treatments. Other nausea caused conditions to include:

  • Early stages of pregnancy
  • Emotional stress
  • Intense pain
  • Gallbladder disease
  • Infections
  • Reactions to certain smells
  • Ulcers
  • Brain tumors that affect the nervous system
  • Bowel obstruction
  • Appendicitis
  • Ingestion of excessive amounts of alcohol

The side-effect of nausea does not always lead to vomiting. For example, anxiety-induced nausea rarely leads to vomiting but is unpleasant, nevertheless, and will often lead to an upset stomach.

Is It Safe to Use CBD as a Nausea Remedy?

According to the World Health Organization (WHO)[5], any reported side-effects of CBD may be due to drug-drug interactions. WHO considers CBD to be a safe alternative treatment for many ailments and states it shows no addictive tendencies.

CBD products that undergo third-party lab testing and can produce a Certificate of Analysis are demonstrating that their CBD products are safe for use by the consumer and don’t contain any harmful pesticides or metals and are the best CBD products from seed to soil.

A look at the table of contents will tell you what is in your CBD product and if there is anything in the product that will make you nauseous, such as gluten. Labels should be scrutinized to make sure your product is safe and has been lab-tested.

Side Effects of CBD for Nausea

Some of the best CBD oil products may give you an upset stomach if your dose is too high. A high CBD intake may not agree with you, the dose may be too high for your body, and your body seeks to eliminate it through an upset stomach, nausea, vomiting, and diarrhea. These symptoms are not uncommon with oils and supplements[6], especially if you ramped up on your dose too quickly, not giving your body enough time to adjust. Or, there could be something in the product that is aggravating your digestive systems, such as the carrier oil used or gluten.

Tiredness and changes in appetite[7] and weight may occur. There may be some drowsiness and light-headedness. Drug interactions may occur since CBD interacts with competing enzyme systems used in drug detoxification and metabolism. Other studies[7] have shown that treatment with doses of CBD oil up to 600 mg had no effect on heart rate or blood pressure.

How to Use CBD Oil for Nausea

The fastest way to get CBD into your bloodstream is through inhalation. If you are struggling with nausea, you probably don’t want to take something orally, and you want it to be fast-acting. Using a vaporizer to breathe the oil as steam will allow you to feel the effects within 30 seconds or less. If you intend to vape your oil, make sure you buy from reputable sources from a supplier with lab-tested cartridges of CBD oil to help you get rid of your nausea. 

Adding a little THC to the therapy may help the nausea CBD is treating by binding to the endocannabinoid system’s CB1 receptors and decreasing nausea by this mechanism. CB1 receptors are present in the brain and central nervous system. Thus, whether full-spectrum, broad-spectrum, or isolated, CBD’s form may make a difference in therapy outcome.

Frequently Asked Questions

Is CBD oil good for nausea?

A study published in the British Journal of Pharmacology stated that a review of the literature supports CBD’s use[1] in nausea and vomiting caused by chemotherapy. If it is useful for causes of nausea induced by medical treatments, chances are it will help nausea caused by other factors. CBD may help get rid of an upset stomach.

Where do you put CBD for nausea?

The best place to put CBD for nausea is in your lungs by steam inhalation or vaping to bypass your upset stomach. The next best site would be to use a spray or tincture that you put under your tongue for absorption into the bloodstream bypassing the digestive system.

What is a good dosage for CBD for nausea?

Always start low and go slow. Try reading the label for directions or asking a health care provider what the best starting dose would be for your condition.

+ 7 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Parker, L.A., Rock, E.M. and Limebeer, C.L. (2011). Regulation of nausea and vomiting by cannabinoids. British Journal of Pharmacology, 163(7), 1411–1422. Available from:
  2. Tramer, M.R. (2001). Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic. BMJ, 323(7303), pp.16–16. Available from:
  3. Parker, L.A. and Limebeer, C.L. (2008). Cannabinoids in the Management of Nausea and Vomiting. Cannabinoids and the Brain, 259–276. Available from:
  4. Rock, E. and Parker, L. (2013). Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats. British Journal of Pharmacology, 169(3), 685–692. Available from:
  5. Geneva (2018). CANNABIDIOL (CBD) Critical Review Report Expert Committee on Drug Dependence Fortieth Meeting. Available from:
  6. Halsted, C.H. (2003). Dietary supplements and functional foods: 2 sides of a coin? The American Journal of Clinical Nutrition, 77(4), 1001S-1007S. Available from
  7. Iffland, K. and Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2(1), 139–154. Available from:

Medically reviewed by:

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.

Medically reviewed by:

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source