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Best CBD Oil For Parkinson’s Disease: Does it really help?

Parkinson’s disease is the second most common neurodegenerative disorder globally. It affects the dopamine-producing brain cells, although the cause remains largely unknown. There is no cure, and treatment currently includes medication and surgery. Although Parkinson’s Disease (PD) itself is not fatal, severe complications can arise, and the Centers for Disease Control list it as the 14th cause of death in the world[1].

The CBD Oil For Parkinson’s (November. 2020)

CBD Oil for Parkinson’s

CBD oil can help in various health issues, significantly in pain and high blood pressure.

Preliminary research[2] has found that CBD oil may help with treating quality of life issues in patients without psychotic symptoms. Another study showed the effectiveness of CBD in the treatment of psychosis in[3] PD patients. The treatment did not worsen motor functions, and one of CBD’s benefits was that it alleviated the psychotic symptoms present in the PD patients. There are clear advantages to using CBD oil for Parkinson’s in the relief of non-movement related symptoms, not to mention it may have neuroprotective effects as part of the treatment.

While few studies exist as to CBD’s potential benefits on movement disorder treatment in PD, clinical and pre-clinical research has shown a reversal of catalepsy in rodent[4] models. And, dose-related improvement in dystonia[5] was noted with CBD oil in five patients in an open-label study on movement disorders. The improvement ranged from 20% – 50% in its effects on dystonia symptoms of Parkinson. More research is needed on CBD’s effects on the nervous system in general and on the motor and non-motor symptoms, specifically in people with Parkinson.

While evidence exists as to the positive effects that CBD may have on PD patients’ quality of life issues, such is not the case for medical marijuana. There is insufficient evidence[6] as of the last updated study in 2020 to indicate medical marijuana’s usefulness to treat PD patients’ motor symptoms. Evidence suggests it should only be considered on a trial basis for non-refractory issues such as pain. Symptoms of Parkinson should be treated with a CBD product as opposed to medical marijuana. Using CBD is safer than medical marijuana for treating Parkinson’s symptoms.

Editor’s Choice

Take Spruce CBD

Spruce CBD

Why is it better?

  • Third-party lab tested
  • 100% natural
  • No pesticides
  • Full Spectrum

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The Lineup At A Glance

Best Quality

  • Broad-spectrum 
  • Wide variety of products
  • Third-party lab tested

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Best Priced

  • CO2 Extraction
  • Organically grown
  • Affordable
  • No pesticides

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Best Absorption

  • Organic
  • Free from THC
  • Uses nanotechnology

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Best Variety

  • Third-party lab tested
  • Organically grown
  • Non-GMO
  • Wide variety of products
  • Full-spectrum

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Top 5 Best CBD oils for parkinson’s disease

Spruce CBD – Editor’s Pick

Take Spruce CBD

 Spruce is a family-run CBD brand that offers high-quality, third-party lab tested, full-spectrum oil made from one of the finest, oldest hemp strains in the United States.

  • Third-party lab tested
  • 100% natural
  • No pesticides
  • Full-spectrum
  • Costs more than average
  • Only two potencies

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Spruce is a CBD brand established in Raleigh, NC, in 2018. The company prides itself on making American-made CBD products.

It obtains its CBD from a time-tested strain grown in the United States for over 200 years. Its CBD is grown on family-run organic farms in North Carolina and Kentucky. Spruce is a full-spectrum oil containing both CBD and THC (at levels < than 0.3%) plus the terpenes, flavonoids, and natural plant nutrients. Spruce have usually rated as one of the best CBD brands for several health issues.

Its CBD is unique in that the extraction is from a moonshine type fashion with the use of alcohol rather than by CO2 extraction. Alcohol extraction is both safe and effective.

CBD Spruce produces a full-spectrum product, meaning you get the full effects of the endocannabinoid system’s effects with all the terpenes, flavonoids, and nutrients from the original plant.

The oil has a pleasant peppermint flavor and comes in two potencies in 30 ml bottles. It comes in 25 mg of CBD per ml (750 mg) and 80 mg of CBD per ml (2400 mg).

Like all good CBD products, Spruce uses third-party testing to guarantee purity and freshness in delivering CBD’s benefits in all of it’s CBD products.

Medterra

Medterra oil -2

This is a pure CBD oil without additives or THC and is highly affordable, making it a solid CBD oil for Parkinson.

  • Broad-spectrum 
  • Wide variety of CBD products
  • Third-party lab tested
  • No flavored options

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Medterra is a reputable brand with various CBD products to choose from, including creams, tinctures, edibles, oils, and supplements.

The gold standard CO2 extraction method is used to remove all impurities and THC.

Its wide variety of products all come with a detailed third-party Certificate of Analysis of its potency and contaminants. Better yet, it is certified by the U.S. Hemp Authority, which issues guidelines on stringent hemp processing.

Some of the products come in liposomal form, a highly bioavailable form of CBD. Other products can combin with synergistic compounds such as melatonin or lemon balm.

There is a full refund policy if you send back the product within 30 days, no questions asked!

Pure CBD

CBDPure CBD Oil_1

CBD Pure offers affordable products that provide excellent results in different dosage options.

  • CO2 extraction
  • Organically grown
  • Affordable
  • No Pesticides

  • Only two choices
  • Limited flavor options

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This organic farm began in 2016 in Colorado with a mission to provide the best CBD product on the market. The farm does not use any pesticides or herbicides on its organic ranch. 

The third-party tests all of their products to guarantee freshness and purity to their customers and even provide a downloadable version of their test to any given location.

They are affordable and even offer coupons to help defray expenses. These coupons are available at check-out for all CBD products.

The natural flavoring is because all of the plant residues were removed during CO2 extraction. It is noticeable in the lack of green tint to the oil, and the softgels are tasteless. Their formula allows for the entourage effect’s full expression, and the oil contains all the terpenes, flavonoids, and nutrients from the original plant. THC is < 0.3%.

To prove confidence in their product, CBD Pure offers a 100% guarantee on all of its products so that if you are not entirely satisfied, you can return the product and get your money back within 90 days.

Joy Organic

Joy Organics CBD Oil

The company prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC, and gluten. It is also organic and Farm Bill compliant[7].

  • Organic
  • Free from THC
  • Nanotechnology
  • Unclear sourcing
  • Lack of international shipping
  • Not recommended for vegans

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Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids in it’s CBD oils! Most of the CBD oils have some THC in them, but Joy Organic does not have a trace of it in their products. However, the user may still benefit from the full entourage effect of all 112 cannabinoids!

The products go through a testing process whereby a Certificate of Quality Assurance and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these are indicators of purity and standard of quality.

Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries.

 The oil products come in four flavors, orange, tranquil, natural, and mint. Along with the four flavors come four different potencies, 250, 500, 1000, and 1500 mg per bottle. The oil itself undergoes a process to make it more bioavailable, a nanotechnology emulsion technique that involves breaking down the molecule into smaller, more digestible components.

The company does not charge for its shipping fees, thus saving the customer valuable money.

CBDfx

CBDfx-Tincture

This innovative company, which started in 2015, hosts a wide variety of products that it sells nationally and internationally.

  • Third-party tested
  • Non-GMO
  • Organically grown
  • Wide variety of products
  • Full-spectrum
  • Important information not readily available
  • Returns are not convenient

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CBDfx extracts its oils from hemp grown in Europe or Kentucky, where it is then shipped to southern California for further processing.

CBDfx uses organic farming techniques and CO2 extraction to guarantee the finest CBD oils it can produce. CO2 is widely considered the safest option for the extraction of hemp.

CBDfx manufactures full-spectrum oil. Being full-spectrum, you are guaranteed the entourage effect that enhances the beneficial functions of CBD. Full-spectrum means you have the advantage of the terpenes, flavonoids, and all the cannabinoids.

The product line is widely diverse, from those supplements made for pets’ use to those for the use of the rest of us like tinctures, oils, drinkable shots, sublingual strips in fun flavors, and capsules. CBD treatment can be fun and full of variety.

What Are the Symptoms of Parkinson’s Disease?

The symptoms of Parkinson are as varied as the disease itself. And, the progression of the illness is individual, some experiencing faster declines in their nervous system function than others. Symptoms fall into two broad classes, motor symptoms and non-motor symptoms. Non-motor symptoms include loss of memory, loss of attention span, constipation, early satiety, sleep disorders, anxiety, pain, vision problems, loss of taste or smell, hallucinations, fatigue, psychotic symptoms, and sweating.  Motor symptoms include tremor, rigidity, slowness of movement, dystonia (involuntary contraction of muscles), drooling, dizziness or fainting, stooped posture, movement disorders, facial masking, uncontrollable movements, and postural instability.

The slowness of movement (bradykinesia) must be present along with rigidity or tremor for a diagnosis[8] of Parkinson’s disease to be made.

Benefits of CBD Oil for Parkinson’s Disease

Parkinson’s Disease represents an inflammatory condition within the brain. One of CBD’s functions is as an anti-inflammatory compound. It mediates the effects of inflammatory[9] cytokines involved in PD’s neuroinflammation. Thus, one of CBD’s potential advantages is that of an anti-inflammatory. CBD may also act as an antioxidant[10] in the oxidative stress associated with PD. CBD might protect the brain cells from oxidation and inflammation.

People with Parkinson’s Disease may have a decreased quality of life. CBD oil for Parkinson may help[11] relieve anxiety, depression, pain, insomnia, and, thus, improve the quality of life. 

CBD Oil Treatment for Parkinson

Does CBD Help Parkinson’s?

CBD hasn’t been used in Parkinson’s Disease patients long term, and there are few studies to rely on for treatment guidance. Recently, a Phase II clinical trial was completed on CBD’s role in the treatment of Parkinson’s Disease. Treatment outcomes were positive[12] for sleep, depression, behavior and emotion, anxiety, and cognition. Improvements in psychotic features were seen as well. About 20-40% of PD patients experience psychotic symptoms[13]. And, treatment with antipsychotics may bring out Parkinson-like symptoms. Taking CBD may relieve pain associated with PD, although research[14] favors THC for this effect. 

CBD oil for Parkinson’s symptom treatment can be in the form of edibles, oils, tinctures, ointments, vape cartridges, and creams. Topical CBD can be used for the muscle spasms so common in patients with PD, and oils can be used to relieve symptoms faster. However, data is lacking regarding this mode of delivery. Tinctures also offer speedy effects as a way to take CBD. The only FDA approved way of taking CBD, however, is through the drug Epidiolex although its benefits have been shown from other CBD oils[15]

What are the Side-Effects of CBD Treatment?

The user of CBD may experience[5] hypotension, dry mouth, sedation, and light-headedness. The most common[16] side-effects of the use of Epidiolex, a CBD isolate, include decreased appetite, diarrhea, liver enzyme elevation, fatigue, malaise, sleep disorders, weight loss, and rashes. Side-effects are seen more often with a higher dose of CBD treatment in people with Parkinson’s Disease.

CBD Oil for Tremors

Acute administration of CBD at a dose of 300 mg significantly reduced tremors[17] in a PD patient put in a high anxiety-producing situation. This study found that having someone take CBD may help with a movement-related disorder in an anxious patient with Parkinson’s..

CBD Oil for Dystonia

An oral dosage of CBD for Parkinson was administered to five patients varying in strength from 100-600 mg/day. Dose-related improvement[5] was noted in all patients, although doses above 300 mg/day increased resting tremor and hypokinesia.

CBD Dosage for Parkinson’s Disease

The recommended dosage for Epidiolex[16], an FDA-approved CBD drug, is to start at 2.5 mg/kg/d twice daily up to a maximum of 10- 20 mg/kg/d. This dose may be higher than what is used in many clinical trials on CBD. This means that an adult weighing 130 lbs., which is 59 kg (130 lbs divided by 2.2 lb/kg), would make 20 x 59 kg = 1180 milligrams of CBD/day taken in divided doses.  This is much higher than what we are seeing in current studies on CBD oil and PD. Doses in clinical trials using CBD oil are using 100-600 mg/day on people with Parkinson’s and finding increased side-effects with dosages higher than 300[5] mg/day. The oil may precipitate unwanted effects at higher doses of CBD. More research is needed to come up with the number of milligrams of CBD to use and the dose of CBD to give per day.

How to Administer CBD Oil for Parkinson’s Disease

Commercial CBD oil may come in 30 ml bottles with a 1 ml dropper in it. The 30 ml vial concentration will differ, so if you have a 500-milligram bottle, each 1 ml dropper will contain 50 milligrams in one dropper-full of CBD. The label should have a table of contents indicating the dose per bottle and dropper. 

 For the fastest absorption and effects of CBD, squeeze the oil onto the back of the underside of your tongue for rapid absorption through the blood vessel located directly under the tongue. Most of the CBD bypasses the gastrointestinal tract, and this increases the rate of absorption.

 The fastest absorption method is achieved with the use of vape pens. You may experience effects within minutes of using a vape pen. CBD’s effects are noted within minutes of vaping.

How to Use CBD Oil for Parkinson’s Disease

Pay attention to your dosage in your use of CBD. It is recommended that you ask your health professional for medical advice, diagnosis, or treatment. Read the label on the bottle for dosage guidance or ask your health care professional for medical advice. It is always good to start with low doses and go slow, paying close attention to how you feel and at what dose your symptoms may improve without making things worse. In no time, you may experience an increase in your quality of life for the long term.

Frequently Asked Questions

Which CBD oil is best for Parkinson’s Disease?

Since research is limited on THC and its effects in Parkinson’s patients, the best CBD oil to go with is purified to contain mostly CBD with little to no THC. A high-quality CBD product that has a Certificate of Analysis and is third-party tested should be chosen.

Can CBD aggravate Parkinson’s Disease?

Yes. It appears that CBD at doses greater than 300 mg/day[16] can aggravate resting tremors and promotes a slowing of movement or bradykinesia.

Which strain of cannabis is best for Parkinson’s Disease?

Ewe-2 Kush is probably the best strain with 1% THC for the person diagnosed with Parkinson.

Is CBD oil good for Parkinson’s symptoms?

CBD’s benefits include the dampening of non-motor and motor symptoms associated with PD. The use of CBD may improve the quality of life of PD patients.

Is CBD legal to use?

Currently, 33 states[14] have legalized CBD for medical use. CBD is legal to sell in all states.

Are there any drug interactions with CBD?

Yes. Potential drug interactions may occur with drugs metabolized by the CYP2C19 enzyme pathway, which include Soma, valproic acid, warfarin, diazepam, Dilantin, and proton-pump inhibitors. Other drug interactions may occur that lessens the effects of amlodipine, atorvastatin, bupropion, fentanyl, topiramate, and others. It is best to consult a pharmacist or other health professional for drug interactions.

What is the best essential oil for Parkinson’s Disease?

Sandalwood oil[20] may act as a neuroprotectant for brain disorders through its antioxidant actions and protection against reactive oxygen species (ROS).

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Parkinson’s Foundation. What Is Parkinson’s?. Available from: https://www.parkinson.org/understanding-parkinsons/what-is-parkinsons
  2. Marcos Hortes N Chagas, Antonio W Zuardi, Vitor Tumas, et al. 2014. Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial. Available from: https://journals.sagepub.com/doi/abs/10.1177/0269881114550355
  3. AW Zuardi, Jas Crippa, JEC Hallak. 2008 [Sep.18, 2008]. Cannabidiol for the treatment of psychosis in Parkinson’s disease. Available from: https://journals.sagepub.com/doi/abs/10.1177/0269881108096519
  4. Fernanda F. Peres, Alvaro C. Lima, Jaime E. C. Hallak, José A. Crippa, Regina H. Silva & Vanessa C. Abílio. 2018 [May 11, 2018]. Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders? Available from: https://www.frontiersin.org/articles/10.3389/fphar.2018.00482/full
  5. Paul Consroe, Reuven Sandyk & Stuart R. Snider. 2009. Open label evaluation of cannabidiol in dystonic movement disorders. Available from: https://www.tandfonline.com/doi/abs/10.3109/00207458608985678
  6. Anastasia Bougea, Christos Koros, Athina-Maria Simitsi, Chrysa Chrysovitsanou, Athanasios Leonardos & Leonidas Stefanis. 2020. Medical cannabis as an alternative therapeutics for Parkinsons’ disease: Systematic review. Complementary Therapies in Clinical Practice. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1744388119309867
  7. Amy Abernethy. 2019 [July 25, 2019]. Hemp Production and the 2018 Farm Bill. Available from: https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019
  8. Parkinson’s Foundation. Movement Symptoms. Available from: https://www.parkinson.org/Understanding-Parkinsons/Movement-Symptoms
  9. Fernanda F. Peres, Alvaro C. Lima, Jaime E. C. Hallak, José A. Crippa, Regina H. Silva & Vanessa C. Abílio. 2018 [May 11, 2018]. Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders? Available from: https://www.frontiersin.org/articles/10.3389/fphar.2018.00482/full
  10. Moisés García-Arencibia, Sara Gonzáleza, Eva de Lago, José A.Ramos, Raphael Mechoulam, Javier Fernández-Ruiz. 2007 [Feb. 23, 2007]. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: Importance of antioxidant and cannabinoid receptor-independent properties, 1134, 162-170. Brain Research. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0006899306034718
  11. Carlos R. Rieder. 2020 [Mar. 24, 2020]. Cannabidiol in Parkinson’s disease, 42(2), 126–127. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115444/
  12. Christopher S. Pauli, Matthieu Conroy, Brian D. Vanden Heuvel & Sang-Hyuck Park. 2020. Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053164/
  13. Laura B. Zahodne & Hubert H. Fernandez. 2011 [Feb. 28, 2011]. Parkinson’s Psychosis. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045857/#:~:text=Approximately%2020%25%20to%2040%25%20of,parkinsonism%20in%20many%20PD%20patients.
  14. Natalie M. Treese. 2020 [Mar. 19, 2020]. Pharmacist’s Guide to CBD Oil. Available from: https://www.uspharmacist.com/article/pharmacists-guide-to-cbd-oil
  15. Junior, N.C.F., dos- Santos-Pereira, M., Guimarães, F.S. et al. 2020. Cannabidiol and Cannabinoid Compounds as Potential Strategies for Treating Parkinson’s Disease and L-DOPA-Induced Dyskinesia, 37, 12–29. Neurotox Res. Available from: https://link.springer.com/article/10.1007/s12640-019-00109-8#citeas
  16. Greenwich Biosciences, Inc. 2018. Epidiolex. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210365lbl.pdf
  17. Stephanie Martins de Faria, Daiene de Morais Fabrício, Vitor Tumas. 2020. Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson’s disease. Available from: https://journals.sagepub.com/doi/abs/10.1177/0269881119895536
  18. A. Mohankumar, G. Shanmugam, D. Kalaiselvi, C. Levenson, S. Nivitha, G. Thiruppathi & P. Sundararaj. 2018. East Indian sandalwood (Santalum album L.) oil confers neuroprotection and geroprotection in Caenorhabditis elegans via activating SKN-1/Nrf2 signaling pathway. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171454/
Kathy Shattler, MS, RDN
About Kathy Shattler, MS, RDN

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.