Strongest CBD Oils 2021 & 10 Most Potent CBD Oil For You

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Updated on - Written by
Medically reviewed by Kimberly Langdon, MD

Strongest CBD Oils

The potency is one of the first things to consider when buying a CBD oil. And how many milligrams (mg) of CBD you are getting for your money is another concern. While there are many things to think about when buying the strongest CBD oil, potency is by far one of the most important considerations. And, you can’t always tell how potent a product is by just looking at the milligrams (mg) of CBD the product has in it. Clearly, if you have two 30 ml bottles and one bottle contains 3,000 milligrams of CBD, and the other contains 6,000 milligrams of CBD, the one that contains the strongest CBD oils is the one you are going to think about buying because you are getting double for the money. 

 But how do you measure strength? We know how to measure the amount. When you are talking about strengths or potency, then you are talking about therapeutic effects. Many people, scientists included, feel that full-spectrum CBD oil or even broad-spectrum CBD oils are more potent than CBD isolates. Bioavailability is another variable, i.e. what technology was used or what carrier oil was used in the final product? Carrier oils increase bioavailability.

Strongest CBD Oil on the market in (June. 2021)

Strongest CBD Oils & Tinctures

The strongest CBD oils start at 33.33 milligrams (mg) per serving, which translates into a 1,000 milligram (mg).,30 ml bottle. This is determined by taking the [amount of CBD in mg] /[bottle size in ml] = strength in mg/ml. Oil brands and tinctures are processed in a manner that may affect bioavailability. Oils are typically extracted from the hemp plant using the gold-standard CO2 extraction, whereas tinctures are extracted using alcohol as a solvent base. The C02 extraction allows for complete extraction of all of the cannabinoids, terpenes, and flavonoids used in the entourage effect that is seen in full-spectrum and broad-spectrum CBD products. The entourage effect allows for the interaction of the minor cannabinoids, terpenes, and flavonoids to synergistically combine with the endocannabinoid system and fully engage the therapeutic effect. 

Tinctures are more bioavailable (20-30%) than oral oils (13-19%), so the administration route makes a difference in potency. Sublingual oils or oromucosal sprays are also more bioavailable than those that pass through the digestive tract. The use of MCT from coconut oil, extra virgin olive oil, or hemp seed oil facilitates absorption of the lipophilic CBD molecule. Keep in mind that edibles have the lowest bioavailabilities.

Editor’s Choice

Take Spruce CBD

Spruce CBD

Why is it better?

  • 100% natural
  • Family- run business
  • Full-spectrum
  • No pesticides

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The Lineup At A Glance

Best Technology

  • High potency available
  • Zero THC, broad-spectrum
  • Nanotechnology

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Best Operation

  • C02 Extraction
  • No pesticides
  • Family-run business
  • Organic

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Best Potency Range

  • Multiple potencies
  • High quality Kentucky hemp
  • MCT Oils

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Best Flavor Options

  • Multiple flavor options
  • Zero THC, broad-spectrum
  • Third-party testing

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Best Range of Products

  • Wide variety of products
  • Gluten free
  • Nanotechnology

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Best Innovation

  • High potency
  • Wide variety of products
  • Liposomal technology

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Best Full Spectrum

  • High potency
  • Full-spectrum
  • Organic

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Best Organic

  • Organic
  • Full-spectrum
  • Hemp seed oil

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Best Potency Level

  • High potency
  • Full-spectrum
  • CBN added

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Top 10 Strongest CBD Oils 2020 2021

Spruce CBD

Take Spruce CBD

Spruce is a family-run CBD brand that offers high-quality, third-party lab tested, full-spectrum CBD oil made from one of the finest, oldest hemp strains in the United States.

  • 100% Natural
  • Family-run business
  • Full-spectrum
  • No pesticides
  • Limited potencies

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Established in 2018, Spruce is a CBD brand based in Raleigh, North Carolina. The company prides itself on making American-made CBD products. 

Spruce stands out from the competition in several ways. For starters, it’s a family-run business, which is a rarity in the CBD industry.  

Its CBD is sourced from a time-tested strain of hemp cultivated in the United States for over two hundred years. This hemp is grown on organic farms in Kentucky and North Carolina. 

Spruce is also unique for using an alcohol extraction method to isolate a CBD-rich extract from hemp. Although most CBD companies use CO2 extraction, alcohol extraction is just as safe and effective.  

Spruce’s CBD oil is made with full-spectrum extract, which means it provides the full content of cannabinoids, terpenes, and other beneficial compounds found in the plant.

It has a pleasant peppermint flavor and comes in 30 ml bottles with two CBD potencies: 750 mg total and 2400 mg. The 2400 mg strength CBD dosage is their high potency option. These are some of the most potent oil drops for the price.

Joy Organics

Joy Organics CBD Oil

Joy Organic prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC and gluten.

  • High potency available
  • Zero THC, broad-spectrum
  • Nanotechnology
  • Unclear sourcing
  • Not for vegetarians
  • No international shipping

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Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids in its CBD products. Most CBD oils have a trace of THC in them, but not Joy Organic! However, the user may still benefit from all 112 cannabinoids’ entourage effect in the zero- content THC version! Full-spectrum CBD oils are also available with both CBD and less than 0.3% of THC to create the full entourage effect.

The CBD products go through a testing process whereby a Certificate of Quality Assurance (COA) and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these are indicators of purity and standards of quality for hemp oil. 

Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries and produce the best CBD oils

The CBD extracts come in four flavors, orange, tranquil, natural, and mint. The four flavors come in different potencies, 250, 500, 1000, and 1500 mg per 30 ml bottle. Their strong potency formula comes in 1350 milligrams of CBD per bottle or 45 milligrams per 1 ml serving. Dosages can be decreased by taking less of a dropper such as .5 ml or .25 ml.

The oils undergo a process to make them more bioavailable, a nanotechnology emulsion technique that involves breaking down the molecule into smaller, more digestible components. This means an effect can be achieved at a lower dose content than that of another technology, theoretically.

CBDPure

CBDPure CBD Oil_1

CBDPure is a family-run business that offers organic hemp-extracted CBD oils at an affordable price.

  • CO2 extraction
  • No pesticides
  • Family-run business
  • Organic
  • Limited flavor choice

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The company does third-party testing with the COA on its products’ purity

for downloading off their website. Their COA outlines cannabinoids, terpenes, solvents, pesticides, microbial growth, and heavy metals.

They are affordable and even offer coupons to help defray expenses. These coupons can be applied at check-out for all CBD products.

They offer one natural flavor in three different concentrations of full-spectrum hemp oils, 300 mg, 600 mg, and 900 mg in 30 cc bottles. Their high strength oil is 1000 mg. of full-spectrum oil.

The company customer service is highly responsive, with a chat window on the website for immediate assistance if needed. They are very customer responsive.
To prove confidence in their product, CBDPure offers a 100% money-back guarantee. If you are not satisfied with the products, return them within 90 days for a refund.

CBDfx

CBDfx-Tincture

The company produces full and broad-spectrum oils in multiple potencies made from high-quality Kentucky hemp and blended with MCT oil makes for high potency CBD oil that is all third-party tested.

  • Multiple potencies
  • High-quality Kentucky hemp
  • MCT oils
  • Limited flavor options

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The company creates tinctures that vary in content from 500-4000 mg and contain the minor cannabinoids CBG and CBN. Their tinctures are both broad-spectrum CBD and full-spectrum CBD tinctures made with MCT oil. High potency CBD oils in the form of tinctures include 4000 mg. in one bottle of CBD oil, which is 133.33 mg of CBD oil per serving and is one of the most potent oils on the market. The CBD tincture comes in wellness and calming potencies and is infused with curcumin and coenzyme Q10.

The tinctures are made with non-GMO, CO2-extracted CBD. To increase their effectiveness, CBDfx infused their CBD tinctures with everything from powerful antioxidants like Curcumin and Coenzyme Q10, the “mother of all cannabinoids” CBG, unique terpene blends, and the ultimate relaxation cannabinoid, CBN.  

CBDfx pills offer a more potent serving size, eliminating the need to consume as much throughout the day or evening.  Whether you’re looking for CBD creams, CBD balms, CBD face masks, CBD facial cleansers, or even CBD serums and massage oil, you can find them all at CBDfx!

Penguin CBD

penguin cbd oil

If you dislike the strong taste of CBD oil, Penguin CBD’s delicious flavor options are sure to give you a pleasant surprise in its products made from all organic hemp. 

  • Multiple flavor options
  • Zero THC, Broad-spectrum
  • Third-party testing

  • New reputation

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Founded in 2019, Penguin CBD is a relatively new CBD brand. It offers a small yet effective THC-free product lineup that includes CBD oil, capsules, gummies, and a cream. 

Penguin’s products are made from organic, non-GMO, Oregon-grown hemp plants. They’re comprehensively tested by a third-party lab, with the COA test results directly available on the company’s website. 

Arguably the biggest strength of Penguin CBD is its wide variety of delicious flavors. The company’s CBD oil is available in natural, mint, citrus, strawberry, and cookies & cream flavors. 

As such, this brand is a good option for people who find the taste of raw CBD oil too strong. 

The oil is formulated with cannabinoid-rich, THC-free hemp extract and comes in four strengths: 8 mg/ml (250 mg total), 20 mg/ml (600 mg), 33 mg/ml (1000 mg), and 83 mg per ml (2500 mg). Penguin CBD offers a high CBD potency option in its 2500 mg CBD oil, and it is one of the most potent oils on the market.

Zero THC products are valuable for people who need to worry about passing a drug test.

American Shaman

CBD American Shaman Oil

The company employs nanotechnology which increases the bioavailability of its CBD products thus decreasing the dose size to achieve effects.

  • Wide variety of products
  • Gluten-free
  • Nanotechnology

  • Higher than average cost

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Only top-grade hemp plants are grown in the U.S. to produce the company’s wide variety of products. 

Huge benefits may be enjoyed through its wholesale program and compassionate care program for veterans and low-income individuals. 

The U.S. Hemp Authority certifies its products. It goes through a lab testing program to ensure quality products free from solvents, microbial contamination, pesticides, and heavy metals. 

It is gluten-free and tested by Ultra Performance Convergence Chromatography. The company uses a CO2 extraction process. 

Its full-spectrum hemp oil is manufactured using nanotechnology, making the molecule smaller and enhancing bioavailability. A 300 mg. per 30 ml bottle is considered strong CBD oil because of the reduced dosage you need to use with this technology.

Sol CBD

Sol CBD Oil

Sol CBD offers a wide range of highly bioavailable CBD products all lab tested for quality.

  • High potency
  • Wide-variety of products
  • Liposomal technology

  • Limited flavor options

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The company offers tinctures, balms, sleep formulas, capsules, balms, and pet supplies from hemp grown in Northern Europe. 

The CBD tincture contains Medium Chain Triglycerides, which add valuable fats and increase absorption of the CBD.  Their strong CBD oil is a 3600 mg. tincture, which has 3x the CBD that their other tinctures have. 

Extraction is by cold processed oil using CO2 extraction techniques to guarantee freedom from contaminants from the cannabis plant, soil, or environment.

The products are all Non-GMO and boast of a higher bioavailability than those products made from nanotechnology.

Royal CBD

royal cbd oil

Royal CBD offers high potency CBD oil farmed on organic ranches and extracted by CO2 methods.

  • High potency
  • Full-spectrum
  • Organic

  • Above-average cost

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Offers high-potency CBD oil sourced from organic sources and lab-tested to guarantee purity and quality.

High-potent oils come in 1000 mg and 2500 mg bottles to provide 33.33 mg – 83.33 mg. CBD per ml.

Royal CBD products are farmed using sustainable farming techniques, producing some of the finest oil drops for the price.

Nuleaf Naturals

NuLeaf Naturals CBD Oil

CO2 extracted, full-spectrum, hemp seed infused CBD oil products all lab tested for purity and quality.

  • Organic
  • Full-spectrum
  • Hemp seed oil

  • Limited flavors

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Colorado-grown full-spectrum CBD oil from organic hemp is NuLeaf’s trademark. It’s high strength strong CBD oils come in bottles of 6,000 mg. concentrates. 

Nuleaf Naturals offers three high strength sizes, 1800 mg, 3000 mg, and 6000 mg. Nuleaf Naturals offers the highest concentration of CBD on the market at 200 mg/CBD per ml serving size. The CBD potency is further amplified by being full-spectrum. 

Independent labs verify that the products are free from contaminants such as mold growth, heavy metals, pesticides, and solvents.

CBDistillery

CBDistillery oil_1

CBDistillery grows its natural full-spectrum and broad-spectrum hemp in a non-GMO environment. 

  • High potency
  • Full-spectrum
  • CBN added

  • Somewhat pricey compared to others

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A full-spectrum CBD type of product is available to those who want to experience the full entourage effect along with a zero THC for those who want that option. The most potent CBD tincture CBDistellery carries is the 2500 mg bottle of CBD. This full-spectrum

CBD oil option provides 83.33 mg CBD per ml. The CBD type most potent is full-spectrum. The CBDistellery produces full-spectrum, broad-spectrum and isolate products.

CBDistellery provides supplements that include the minor therapeutic cannabinoids CBN and CBG along with other products which include oils, tinctures, capsules, vapes, gels, gummies, topicals and powders.

What Are The Strongest CBD Products

NuLeaf offers the most potent CBD concentration for the price of $0.07 cents a milligram for a total of 6000 mg. per 30 ml bottle. Sol CBD also provides a concentrated CBD extract with 3600 mg. of liposomal emulsion for $0.09 cents per milligram. How much CBD is in one dose determines the dose’s size and the number of times you need to dose per day. How much CBD is in the dose determines whether the extract is effective or not.

 The dose’s size does not seem to increase side-effects except in the term of isolates where liver enzymes may become elevated, and other gastrointestinal symptoms noted. Epidiolex], the isolate form of CBD approved by the Food and Drug Administration (FDA), has shown significant side-effects with high doses of this product. However, more research needs to be done on the upper limit of dosages for cannabis extracts as opposed to isolates.

How Do I Determine CBD Oil Strength? 

CBD alone[1] is insufficient for determining the potency of CBD products. Despite legal entanglements, full-spectrum oils offer a synergy between constituents that are not seen with isolated CBD. Furthermore, the side-effects of mixed cannabinoids are smaller than those found with isolated CBD[1]. To determine CBD oil strength, look at the Certificate of Analysis (COA) to determine the serving size and the mg. per serving. Look to see the total milligrams of CBD per bottle.  Consider the route of administration, is it oral or through the bloodstream? Distillates or oils put under the tongue or taken via oromucosal mechanisms are more potent than those that pass through the digestive tract.

Benefits of Strong CBD

There are several benefits to using a strong CBD. There are conditions better treated with higher doses than with lower doses, such as with pain where dosages are difficult to calculate[2] and often err on the high side. The type of pain may differentiate the dose-response. A study[3]on fibromyalgia on a 1:1 ratio of THC and CBD( 13.4-mg THC, 17.8-mg CBD) showed a 30% reduction in pain as compared to the other three-dose modifications with variable levels of THC and CBD. More patients with epilepsy treated with[4] high CBD concentrations of a full-spectrum extract were successfully treated than those treated with a lower dose of purified CBD isolate. A high amount of CBD[5] alone and in combination with a low dose of tetrahydrocannabinol relieved neuropathic pain in an animal model.

A high dose or potent CBD can allow you to lower your amount and not dose as frequently, thus saving money. Consumer health information surrounding doses of CBD are often confusing, so check with your health provider before you check your browser on your computer.

What are Average Amounts of CBD Used in Studies

Most human studies[6] use 20-1500 mg. per day. The amount of CBD you should take depends on a range of conditions:

  • Your body weight
  • The condition being treated
  • The strength of the product being taken
  • Your individual metabolism

Risks of Strong CBD

Although CBD is well-tolerated, excessive doses may cause dry mouth, diarrhea, reduced appetite, and fatigue. CBD can also cause drug interactions, which is the most important side-effect to watch for. Keep in mind that an accepted upper dosage for the FDA approved drug, Epidiolax is 20 mg/kg, which for the average person would be about 1454 mg. for a 160 lb. man. Start low and go slow when beginning a CBD dosage regimen.

Frequently Asked Questions

How is CBD potency measured?

It is measured by taking the total number of milligrams in the bottle and dividing it by the total milliliters in the bottle.

What happens if you take too much CBD?

You may experience some side-effects such as dizziness, diarrhea or fatigue. Extreme amounts may elevate liver enzymes. Any amount may cause a drug interaction.


+ 6 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Yasuyo Urasaki, Cody Beaumont, Michelle Workman, Jeffery N. Talbot, David K. Hill, Thuc T. Le. (2020). Potency Assessment of CBD Oils by Their Effects on Cell Signaling Pathways. Available from: https://www.mdpi.com/2072-6643/12/2/357/htm
  2. Shafik Boyaji, Justin Merkow, R. Noel M. Elman, Alan D. Kaye, R. Jason Yong & Richard D. Urman. (2020).The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence.  Available from: https://link.springer.com/article/10.1007/s11916-020-0835-4
  3. Tine van de Donk, Marieke Niesters, Mikael A. Kowal, Erik Olofsen, Albert Dahan, and Monique van Velzena. (2019). An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430597/
  4. Fabricio A. Pamplona, Lorenzo Rolim da Silva, Ana Carolina Coan. (2018). Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis. Available from: https://www.frontiersin.org/articles/10.3389/fneur.2018.00759/full?utm_term=software%20de%20business%20intelligence&utm_campaign%5b0%5d=aon&utm_campaign%5b1%5d=%5bSearch%5d%20BI%202018&utm_medium%5b0%5d=search&utm_medium%5b1%5d=ppc&utm_source%5b0%5d=google&utm_source%5b1%5d=adwords
  5. Kirsten M King, Alyssa M Myers, Ariele J Soroka‐Monzo, Ronald F Tuma, Ronald J Tallarida  Ellen A Walker, Sara Jane Ward. (2017). Single and combined effects of Δ9‐tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy‐induced neuropathic pain. Available from: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13887
  6. Healthline. (2020). CBD Dosage: Figuring Out How Much to Take. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430597/

Medically reviewed by:

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.