02:19pm Friday 15 December 2017

New Research Shows Certain Genetic Profiles Increase Risk of Coronary Artery Disease, While Others Increase Risk of Heart Attack

(PHILADELPHIA) – Coronary artery disease (CAD) is the single largest cause of death in adults in the United States. Until recently, the genetic basis of CAD has been largely unknown, with just a few proven genes (typically genes for cholesterol disorders) accounting for very little of the disease in the population. Now, a new study from researchers at the University of Pennsylvania School of Medicine shows that certain genetic profiles increase risk of coronary artery disease (CAD) while others uniquely increase risk of heart attacks in those with CAD. The findings, published online first today and in an upcoming edition of The Lancet, are the results of the analysis of two genome-wide association studies (GWAS) — an examination of all or most of the genes (the genome) of different individuals to identify common genetic factors that influence disease.

Lead author Muredach P. Reilly, MBBCH, MSCE, associate professor of Medicine and Pharmacology at Penn, and colleagues compared 12,393 individuals with CAD disorder with 7,383 controls who did not have CAD to identify loci that predispose to angiographic CAD. To identify loci that predispose to heart attacks, they compared 5,783 patients who had angiographic CAD and had a heart attack with 3,644 who had angiographic CAD but no heart attack.

The researchers identified a new locus, ADAMTS7 (a gene already implicated in arthritis), which increased the risk of developing CAD. In the heart-attack comparison, the authors found a new association at the ABO blood group locus. They found that the same gene that codes for the enzyme behind people being blood group O offered protection against heart attacks.

For more information, please see the Lancet’s press release on the study.
http://www.thelancet.com/press-room

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Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $4 billion enterprise. 

Penn’s School of Medicine is currently ranked #2 in U.S. News & World Report‘s survey of research-oriented medical schools and among the top 10 schools for primary care. The School is consistently among the nation’s top recipients of funding from the National Institutes of Health, with $507.6 million awarded in the 2010 fiscal year. 

The University of Pennsylvania Health System’s patient care facilities include: The Hospital of the University of Pennsylvania – recognized as one of the nation’s top 10 hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital – the nation’s first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2010, Penn Medicine provided $788 million to benefit our community.


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