International trial finds polypill halves predicted heart disease and stroke risk

Dr Reddy's pill

The once-a-day polypill contains aspirin and agents to lower blood pressure and cholesterol. These drugs are currently prescribed separately to millions of patients and are known individually to cut the risk of disease, but many experts believe that combining them into a single pill will encourage people to take the medications more reliably.

The trial [1] tested the effectiveness and tolerability of the polypill in 378 people with raised risk of cardiovascular disease, who did not necessarily have high blood pressure or cholesterol, against a placebo. The participants came from the UK, Australia, Brazil, India, New Zealand, The Netherlands and the USA, with core funding for the central coordination of the trial provided by the Wellcome Trust.

“The results show a halving in heart disease and stroke can be expected for people taking this polypill long term,” said Professor Anthony Rodgers of The George Institute for Global Health, who led the international consortium.

“We know from other trials that long term there would also be a 25-50 per cent lower death rate from colon cancer, plus reductions in other major cancers, heart failure and renal failure,” Professor Rodgers said. “These benefits would take several years to ‘kick in’, but of course one of the hopes with a polypill is it helps people take medicines long term.”

National trials of similar combination ‘polypill’ treatments have previously been conducted in India, Iran and Sri Lanka, but this is the first trial to combine data from patients at international centres and the first to look reliably at the incidence of side-effects against a placebo.

The authors noted that the benefits, while large, were not as massive as previous researchers have suggested, and the side-effects were also not as rare as first thought. In the short term, about 1 in 6 people experienced a side-effect. Most were mild, but about 1 in 20 overall stopped treatment due to side-effects, indicating that treatment is best targeted to those at raised risk of disease.

Professor Simon Thom of Imperial College London, who led the UK arm of the trial, commented: “We now need to conduct larger trials to test whether these medicines are best provided in the form of a polypill, or as separate medicines, and whether this combination strategy improves patient adherence to cardiovascular medication.”

This polypill will be available in India soon and elsewhere within a few years, according to regulatory timelines within each individual country.

Dr Ted Bianco, Director of Technology Transfer at the Wellcome Trust, commented: “Few of us would dissent from the view that prevention is better than cure in most matters medical. It is good news, indeed, to see the evidence base grow for the potential use of a new generation of combination products as a safe and affordable option in the battle against heart attack and stroke.”

In the UK, around one in three of all deaths are attributable to cardiovascular disease [2]. Globally, around 80 per cent of all deaths from cardiovascular disease and diabetes occur in low- or middle-income countries, according to recent estimates [3].

In 2001, the World Health Organisation and the Wellcome Trust convened a meeting of experts to discuss affordable interventions for non-communicable diseases, including the potential of a fixed-dose combination pill to reduce the risk of cardiovascular diseases. From here a programme of research was outlined to assess whether this approach is safe, effective and practical.

Additional funding for the trial was provided by the British Heart Foundation, the Health Research Council of New Zealand, the National Heart Foundation of New Zealand, the National Health and Medical Research Council of Australia and the Brazilian Ministry of Health.

Image: A polypill, as used in the study. Credit: Dr Reddy’s (Hyderabad).



Jen Middleton
Media Officer, Wellcome Trust
020 7611 7262
07989 346 658
[email protected]



[1] Program to Improve life and Longevity (PILL) Collaborative Group. An international randomized placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk. PLoS ONE 2011 [epub ahead of print]
[2] British Heart Foundation
[3] World Health Organisation

Notes to editors


The study was conducted by the Program to Improve life and Longevity (PILL) Collaborative Group, part of a larger collaboration known as the Single Pill to Avert Cardiovascular Events ( SPACE).

The polypill was manufactured and provided by Dr Reddy’s Ltd, Hyderabad. The trial was run by an independent research group, and sponsors had no role in the design, conduct or analysis of the trial.

About the Wellcome Trust
The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. It supports the brightest minds in biomedical research and the medical humanities. The Trust’s breadth of support includes public engagement, education and the application of research to improve health. It is independent of both political and commercial interests.

About Imperial College London
Consistently rated amongst the world’s best universities, Imperial College London is a science-based institution with a reputation for excellence in teaching and research that attracts 14,000 students and 6,000 staff of the highest international quality. Innovative research at the College explores the interface between science, medicine, engineering and business, delivering practical solutions that improve quality of life and the environment – underpinned by a dynamic enterprise culture.

Since its foundation in 1907, Imperial’s contributions to society have included the discovery of penicillin, the development of holography and the foundations of fibre optics. This commitment to the application of research for the benefit of all continues today, with current focuses including interdisciplinary collaborations to improve global health, tackle climate change, develop sustainable sources of energy and address security challenges.

In 2007, Imperial College London and Imperial College Healthcare NHS Trust formed the UK’s first Academic Health Science Centre. This unique partnership aims to improve the quality of life of patients and populations by taking new discoveries and translating them into new therapies as quickly as possible.

About the British Heart Foundation
The British Heart Foundation (BHF) is the nation’s heart charity, dedicated to saving lives through pioneering research, patient care, campaigning for change and by providing vital information. But we urgently need help. We rely on donations of time and money to continue our life-saving work. Because together we can beat heart disease.