12:26pm Tuesday 12 December 2017

Depressed heart function from stress improved by a simple sugar

When blood flow to the heart is stopped (during heart surgery) or slowed by a heart attack, the heart is stressed and may begin to function poorly, progressively worsen and end up in heart failure.

In a model of open heart surgery, researchers found that stopping blood flow to the heart for 20 minutes significantly depressed both the levels of the energy carrying molecule, and the function of the heart, which required days for recovery. 

Synthesizing more ATP is limited by the production of ribose, a simple sugar the cells make very slowly. The researchers provided ribose intravenously, which passed into the heart cells and speeded the recovery of both heart function and energy levels from ten days to just over two days. Moreover, in a second model giving intravenous ribose for two weeks after a heart attack in rats prevented in large part the deterioration of the rest of the heart and preserved its function. These studies show that the stresses which produce lower energy levels and lead to failure can be greatly improved by enhancing the production of the ATP energy molecule by giving the simple sugar, ribose.

Note: Actual presentation time is 6:30 p.m. CT, Tuesday, July 19, 2011.

Author disclosures are on the abstracts.

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Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing science content. Revenues from pharmaceutical and device corporations are available at www.americanheart.org/corporatefunding.

NR11- 1103 (2011/BCVS Tips)

Abstract P139

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