The “uptake capacity” for cholesterol can be measured with a short processing time (within 6 hours), and is highly reproducible. It also shows good correlation with the conventional “extraction” capacity for cholesterol (figure 2). The study proved that this marker can be used to prevent and monitor cardiovascular conditions with the same effectiveness as the conventional method. The team also clarified that the uptake capacity for cholesterol had fallen in patients with cardiovascular disease (figure 3). They confirmed that this marker is a negative risk factor independent of bad cholesterol (LDL) and good cholesterol (HDL) (figure 3).

The research team is currently using this marker on a larger population to confirm the effect of decreased HDL capacity on the prevention and control of cardiovascular disease. The results of this study could help in creating strong core technology to develop drugs that improve HDL’s function.

figure 2
figure 3
Journal information
Paper
Cholesterol Uptake Capacity: A New Measure of HDL Functionality for Coronary Risk Assessment
doi:10.1373/jalm.2016.022913
Authors
Amane Harada1, Ryuji Toh2, Katsuhiro Murakami1, Maria Kiriyama1, Keiko Yoshikawa1, Keiko Miwa1, Takuya Kubo1, Yasuhiro Irino2, Kenta Mori3, Nobuaki Tanaka3, Kunihiro Nishimura4, Tatsuro Ishida3, Ken-ichi Hirata2,3

  • 1 Central Research Laboratories, Sysmex Corporation
  • 2 Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of
  • Medicine
  • 3 Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
  • 4 Department of Preventive Medicine and Epidemiologic Informatics, Office of Evidence-Based Medicine and Risk Analysis, National Cerebral and Cardiovascular Center
Journal
The Journal of Applied Laboratory Medicine: An AACC Publication

KOBE UNIVERSITY