The new analytical approach, called “mixed modeling of meta-analysis P-values” or MixMAP, offers new and complementary information as compared to single nucleotide polymorphism-based analysis approaches that have been used in past studies to identify novel genes linked to heart disease. The researchers say the tool is straightforward to implement and can be used with freely available computer software. The approach may also be applied broadly to advance genetic knowledge of many other diseases.
“The MixMAP approach provides a significant advance by unlocking more information regarding the genetic basis of disease using existing large data and at little additional cost to the research community and funding agencies,” said Muredach P. Reilly, MBBCH, MSC, associate professor of Medicine at Penn and senior study author. “For complex diseases such as heart attack and diabetes, this provides a real opportunity to generate substantial new knowledge and advance treatment and diagnostic opportunities.”
For more information, please see the University of Massachusetts Amherst news release.
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