05:35am Saturday 19 October 2019

Vitamin D supplements may help blacks lower blood pressure

Study Highlights:

  • Vitamin D supplements may help African-Americans lower their blood pressure.
  • After three months, systolic blood pressure decreased for every 1000 units of vitamin D taken daily.
  • Additional studies in larger groups of African-Americans are necessary to confirm the findings.

In the prospective trial, a three-month regimen of daily vitamin D increased circulating blood levels of vitamin D and resulted in a decrease in systolic blood pressure ranging from .7 to four mmHg (depending upon the dose given), compared with no change in participants who received a placebo.

Systolic blood pressure, the top and highest number in a reading, is pressure in the arteries when the heart beats. Diastolic blood pressure, the bottom and lower number, is pressure in the arteries between heart beats.

 “Although this needs to be studied further, the greater prevalence of vitamin D deficiency among African-Americans may explain in part some of the racial disparity in blood pressure,” said John P. Forman, M.D., M.Sc., lead author of the study and Assistant Professor of Medicine in the Renal Division and Kidney Clinical Research Institute at Brigham and Women’s Hospital in Boston, Mass.

African-Americans have higher rates of hypertension and lower levels of circulating 25-hydroxyvitamin D (vitamin D3 or cholecalciferol) than the rest of the U.S. population. Few studies have included enough African-Americans to determine whether vitamin D supplements might reduce the racial disparity.

To explore this, researchers from seven major teaching hospitals conducted a four-arm, randomized, double-blinded study of 250 black adults. They tested blood pressure after a three-month regimen of daily vitamin D supplementation at one of three doses, and compared the findings with a group taking placebo vitamins:

  • Taking 1,000 units of vitamin D each day for three months was associated with a .7 mm Hg decrease in systolic blood pressure.
  • Taking 2,000 units was linked to a 3.4 mm Hg decrease.
  • Taking 4,000 units netted a 4 mm Hg drop.
  • Participants taking placebo supplements had an average increase of 1.7 mm Hg.

“The gains we saw were significant but modest,” Forman said.

Furthermore, diastolic blood pressure didn’t change in any of the four groups.

In prospective studies, lower blood levels of 25-hydroxyvitamin D have been independently linked with an increased risk of developing hypertension.

 “If vitamin D supplementation lowered blood pressure among African-Americans, its widespread use could have major public health benefits,” said Andrew T. Chan, M.D., M.P.H., co-author of the study and Assistant Professor of Medicine in the Division of Gastroenterology at Massachusetts General Hospital.

Co-authors are: Jamil B. Scott, M.P.H., Ph.D.; Kimmie Ng, M.D., M.P.H.; Bettina F. Drake, Ph.D., M.P.H.; Elizabeth Gonzalez Suarez, M.A.; Douglas L. Hayden, M.A.; Gary G. Bennett, Ph.D.; Paulette D. Chandler, M.D., M.P.H.; Bruce W. Hollis, Ph.D.; Karen M. Emmons, Ph.D.; Edward L. Giovannucci, M.D., Sc.D.; and Charles S. Fuchs, M.D., M.P.H.

The study was conducted at the Dana-Farber Cancer Institute in Boston, Mass., and was funded by the National Institutes of Health, Department of Defense Prostate Cancer Research Program, American Society of Clinical Oncology Career Development Award and Pharmavite LLC in Mission Hill, Calif.

Author disclosures are on the manuscript.

For additional information on blood pressure, visit:

For the latest heart and stroke news, follow us on Twitter: @HeartNews.


Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association’s policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at www. heart.org/corporatefunding.

Additional resources, including multimedia, are available in the right column of this link: http://newsroom.heart.org/news/vitamin-d-supplements-may-help-blacks-lower-blood-pressure?preview=a12505437d4520e725af8060d5a62a9d

For Media Inquiries: (214) 706-1173
CONTACT: For journal copies only,
please call: (214) 706-1173
For other information, call:
Karen Astle: (214) 706-1392
Carrie Thacker: (214) 706-1665
Julie Del Barto (broadcast): (214) 706-1330
For Public Inquiries: (800) AHA-USA1 (242-8721)

Share on:

MORE FROM Blood, Heart and Circulation

Health news