Although stem cells are present in the heart throughout life, exactly where they reside and how to best coax them into action in patients with acute or chronic heart disease, remains poorly understood.
The six year $6million USD grant awarded by the France-based Fondation Leducq Transatlantic Networks of Excellence will enable this multi-disciplinary international team to reveal more about cardiac stem cells and their role in heart function and repair.
Consortium members includes Professor Richard Harvey from the Victor Chang Cardiac Research Institute and Professor Nadia Rosenthal from the Australian Regenerative Medicine Institute at Monash University and Imperial College, London, as well as researchers from US National Institutes of Health, Universite De Pierre et Marie Curie-Sorbonne Universite, Max Planck Institute for Heart and Lung Research, Mount Sinai School of Medicine and San Diego State University. The consortium is headed by Professors Torn Finkel and David Sassoon.
Commenting on the grant, Professor Rosenthal said, “The last decade has seen a tremendous interest in the possibility that cardiac stem cells could be used to help patients. However, we need to better understand their characteristic rolesand interactions with other cells of the heart if we are to develop sophisticated regenerative therapies for the future.
This grant provides an unprecedented opportunity to bring together experts from across the world to comprehensively evaluate these cells.”
Professor Martin Pera, Chair of Stem Cell Science at The University of Melbourne and Program Leader of Stem Cells Australia commented, “Nadia Rosenthal and Richard Harvey are leading cardiac stem cell researchers and their involvement in this prestigious grant, and the international consortium it supports, will enhance the profile of Australian research in this field and accelerate the translation of basic discoveries in heart regeneration towards clinical application.”
Professors Rosenthal and Harvey lead Stem Cells Australia’s Cardiac Regeneration and Repair Program.