07:18am Saturday 22 July 2017

Miniature human hearts created from rat hearts

PORTLAND, OREGON — A miniature human heart created by introducing human cells into the matrix of a whole rat heart may make it easier to confirm basic science findings and test potential new heart drugs for safety and efficacy, according to a preliminary study presented at the American Heart Association’s Basic Cardiovascular Sciences 2017 Scientific Sessions.

For years, researchers have used the Langendorff method to remove the heart from an animal in order to introduce fluid through the aorta, the body’s largest vessel, then into the artery network of a heart. This method is also used to deliver solutions that strip away cells from the rat heart before introducing the human cells to model a human heart.

In the current study, researchers used a technique called 4-Flow cannulation, which introduces solution not just into the arteries but into the veins’ network of the heart. This system allowed the researchers to strip rat cells while preserving the lining matrix of the whole heart to repopulate with human cells. Unlike the Langendorff perfusion, 4-Flow cannulation enabled the researchers to preserve the circulation within the entire heart to maintain the normal flow and in addition to stimulate the mechanical expansion heart chambers.

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Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at www.heart.org/corporatefunding.

About the American Heart Association

The American Heart Association is devoted to saving people from heart disease and stroke –  the two leading causes of death in the world. We team with millions of volunteers to fund innovative research, fight for stronger public health policies, and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation’s oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1-800-AHA-USA1, visit heart.org or call any of our offices around the country. Follow us on Facebook and Twitter.

For Media Inquiries and AHA Spokesperson Perspective:  (214) 706-1173

Akeem Ranmal: (214) 706-1755; akeem.ranmal@gmail.com

For Public Inquiries: (800) AHA-USA1 (242-8721)

 

 


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