Depending on the severity and type, cardiac arrhythmias – disturbances to the heart’s normal electrical rhythm causing an irregular heartbeat – can lessen the quality or length of a person’s life and in extreme cases can even cause sudden death.
In some cases certain medicines can affect the normal electrical activity of the heart and cause these arrhythmias.
The Bristol research team will study whether low levels of the antibiotic, erythromycin, can block such effects and will further investigate the mechanisms involved. It may lead to new ways of preventing or treating harmful drug-induced cardiac side effects.
The two-year project, led by Professor Jules Hancox and Dr Chris Dempsey,has been given a research grant of £117,433 from Heart Research UK.
Sometimes patients taking drugs to treat medical conditions suffer adverse side effects affecting their heart. Evidence shows that up to three per cent of patient prescriptions are for drugs with some potential to cause arrhythmia, so the number of patients exposed to this risk is sizeable.
Certain factors can worsen the risk of drug-induced cardiac arrhythmia but it is not yet possible to predict or avoid all cases of drug-induced arrhythmias.
Professor Jules Hancox, from the School of Physiology and Pharmacology, said:“We are delighted to have received this support from Heart Research UK for this important research project, which will allow us to explore new ways to offset unwanted side effects of drugs on the heart.”
Barbara Harpham, National Director of Heart Research UK said: “Irregular heart rhythms are potentially serious and this interesting project will investigate treatments for arrhythmias caused by other medicines. Our aim with grants like this is to support cutting-edge science with the potential to benefit patients as soon as possible.”
About Heart Research UK
Heart Research UK is a visionary charity that funds ground-breaking medical research into the prevention, treatment and cure of heart disease. Having funded six of the first eight successful UK heart transplants, Heart Research UK has been helping hearts by supporting clinical and surgical projects and young researchers on their first steps into research.
Since the charity was formed in 1967 it has funded over £21m on research projects in hospitals and universities across the UK. Since the start of its Healthy Heart Grant programme in 2001, it has also awarded over £1.75m to community- based lifestyle projects that aim to prevent or reduce the risks of heart disease. What’s raised locally is spent on local projects.