12:24am Tuesday 24 October 2017

Not a sweet heart: Researchers find bitter taste receptors on human hearts

Professor Walter Thomas.
Professor Walter Thomas.

The School of Biomedical Sciences team was able to observe the presence of the receptors as part of their ongoing research into the growth of human hearts during disease.

Research team leader and Head of the School Professor Walter Thomas said the team would investigate the phenomenon, which was originally discovered by former UQ PhD student Dr Simon Foster. Dr Foster’s findings are published in The Journal of the Federation of American Societies for Experimental Biology here.

 “Dr Foster was able to show that around 12 taste receptors, particularly those that respond to bitter compounds, were expressed in human hearts,” Professor Thomas said.

“This is quite remarkable, as the human genome only has 25 of these bitter taste receptors, and we wanted to find out why half of them were located in the heart.

“When we activated one of the taste receptors with a specific chemical that we all taste as bitter, the contractile function of the heart was almost completely inhibited.

“While the underlying physiology behind this phenomenon remains unclear, this is now a major area of ongoing investigation.”

The research team’s primary focus is on is how the heart grows normally as well as abnormally in disease.

“After hypertension or a heart attack, the heart frequently undergoes compensatory growth in order to maintain the circulation of blood around the body,” Professor Thomas said.

“But a common end result of this compensatory growth is eventual heart failure, a major cause of death in Australia.

“During laboratory tests, we were looking at all the genes that are regulated in the heart in this growth phase.

“We found the rodent heart cells we were working with contained smell and taste receptors, which are normally considered to be only present in the nose and mouth.”

Professor Thomas said the project progressed from animal studies to human investigations through collaborations with the Prince Charles Hospital in Brisbane.

“Using heart tissue from humans undergoing heart surgery, such as valve replacement and coronary arterial bypass, we replicated the rodent laboratory experiments and found taste receptors were also present in the human heart,” he said.

Professor Thomas said Dr Foster had been awarded a two-year Danish Council for Independent Research Medical Sciences postdoctoral fellowship of $A356,000.

The 17 annual Danish fellowships are highly contested internationally and are offered to provide younger researchers with the optimal conditions for producing outstanding research results at a high international level.  Dr Foster will take up his Fellowship in Denmark in June.

Media:  Professor Walter (Wally) Thomas, +61 7 3365 2905, w.thomas@uq.edu.au or Lynda Flower, +61 7 3365 1536, l.flower@uq.edu.au.


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