Sex-Specific Biomarkers Are Needed to Learn Why Heart Attacks Kill More Women Than Men

The need for sex-specific biomarker and risk stratification tools to improve diagnosis and treatment is clearly described in the Editorial “Sex, Myocardial Infarction, and the Failure of Risk Scores in Women,” published in Journal of Women’s Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women’s Health website until September 30, 2015.

Shilpa Agrawal, Jennifer Van Eyk, PhD, Kimia Sobhani, PhD, and C. Noel Bairey Merz, MD, David Geffen School of Medicine, University of California, Los Angeles and Cedars-Sinai Medical Center, Los Angeles, CA, highlight an article by Eva de-Miguel-Balsa, MD, Hospital General Universitario de Elche, Spain, and colleagues in Journal of Women’s Health, in which the researchers report that women with acute myocardial infarction and ST segment elevation had delayed access to care and reperfusion therapy and were more likely to die in the hospital. A comparison of the different risk scores used to evaluate this study group showed that the scoring systems are not sufficient to explain the sex-related mortality gap present in this study and that persists in the medical literature.

“Since the mortality rate of women from cardiovascular disease remains higher than men and current risk scoring systems are not as useful in women, the development of sex-specific risk stratification tools is needed in order to improve the diagnosis and treatment of cardiovascular disease in women,” says Editor-in-Chief Susan G. Kornstein, MD, Executive Director of the Virginia Commonwealth University Institute for Women’s Health, Richmond, VA, and President of the Academy of Women’s Health.

Work reported in this publication was supported by the National Heart, Lung, and Blood Institutes under contracts N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164, RO1-HL-073412-01, and grants U0164829, U01 HL649141, and U01 HL649241. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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About the Journal
Journal of Women’s Health, published monthly, is a core multidisciplinary journal dedicated to the diseases and conditions that hold greater risk for or are more prevalent among women, as well as diseases that present differently in women. The Journal covers the latest advances and clinical applications of new diagnostic procedures and therapeutic protocols for the prevention and management of women’s healthcare issues. Complete tables of content and a sample issue may be viewed on the Journal of Women’s Health website. Journal of Women’s Health is the official journal of the Academy of Women’s Health and the Society for Women’s Health Research.

About the Academy
Academy of Women’s Health is an interdisciplinary, international association of physicians, nurses, and other health professionals who work across the broad field of women’s health, providing its members with up-to-date advances and options in clinical care that will enable the best outcomes for their women patients. The Academy’s focus includes the dissemination of translational research and evidence-based practices for disease prevention, diagnosis, and treatment of women across the lifespan.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Violence and Gender, LGBT Health, Population Health Management, and Breastfeeding Medicine. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.