“Our research suggest that patients who have been operated for aortic coarctation should receive lifelong follow-up,” says Haki Jashari, doctoral student at the Department of Public Health and Clinical Medicine.
“It is well established that delayed intervention is associated with undesirable consequences on heart function. But our findings show that even in the absence of symptoms, disturbed heart function was still evident two years after being operated within the first month of life, irrespective of infrequent post-operative hypertension.”
According to Haki Jashari, the best method to assess the impact of aortic coarctation on heart function post-surgery is the non-invasive ultrasound method, equipped with recent echocardiographic modalities. This widely used method is radiation free, inexpensive and patient-friendly.
Ultrasound image showing narrowing (indicated by arrow) of the aorta. Photo: Haki Jashari.
Coarctation of the aorta is a congenital heart disease, where the main artery coming out of the heart is narrowed just after it branches for the upper body. The narrowing results in high blood pressure in the upper body and low pressure in the lower body. Severe cases presented in the neonatal period can lead to heart failure, while mild narrowing may go unnoticed and is often first diagnosed in childhood or even later. Usually by then, the heart has already responded to the increased pressure with wall thickening. However, the recent data suggest that aortic coarctation represents a much more complicated stiffness of the vasculature rather than just a simple narrowing of the aorta.
Haki Jashari comes from Pristina, Kosovo, where he works as resident doctor in Pediatrics. He is a doctoral student in the Department of Public Health and Clinical Medicine, Umeå University.
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About the disputation:
On Wednesday 21 December, Haki Jashari, Department of Public Health and Clinical Medicine, will defend his thesis titled: The effect of pressure afterload due to aortic coarctation on left ventricular function in children. Opponent: Professor Katarina Hanséus, Institutionen för kliniska vetenskaper, Lunds Universitet. Principal supervisor: Professor Michael Henein.
The dissertation defence will take place at 09:00 am in Room D, Unod T9, University Hospital of Umeå (NUS).
Editor: Daniel Harju
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