The joint disease osteoarthritis is one of our most common chronic diseases and one of the primary causes of disability for people around the world.
“Osteoarthritis often attacks the knee and hip joints and breaks down the impact absorbing cartilage found there. For those affected, the progression of the disease usually takes many years, with gradually increasing pain which often leads to disability”, says Carl Siversson, who has just defended his thesis in Medical Radiation Physics at Lund University in Sweden.
One of the problems with osteoarthritis has been diagnosing and monitoring the disease before symptoms become evident. It has therefore been difficult to change or delay the course of the disease. A few years ago, researchers from Lund University and Harvard Medical School developed a method to measure the degree of osteoarthritis using an MRI scanner, even at a very early stage. The method is called dGEMRIC (delayed gadolinium-enhanced MRI of cartilage).
“This was major progress, but one problem was that the measurements could only be performed in a limited part of the cartilage. We have now improved the method so that we can study all the cartilage in the joint at once. We have achieved this by solving the problem of how to correct all the irregularities in the MRI images”, says Carl Siversson.
The improved method has now been tested both on healthy individuals and on individuals with osteoarthritis, and the results show that the disease can now be monitored in ways that were not previously possible, according to Carl Siversson.
“Now we are continuing our work to make the method easy for doctors to use in their practice. Our hope is that the method will also be significant for future drug development”, says Carl Siversson, who after completing his PhD will continue his research at Harvard Medical School in Boston, USA.
The new method is described in Carl Siversson’s thesis: Three-dimensional T1 quantification techniques for assessment of cartilage quality using dGEMRIC
Carl Siversson, mobile +46 708 204876, [email protected]
Katrin Ståhl, [email protected], +46 46 222 0131
The improved method takes three-dimensional images of the joint, in which disease-related cartilage changes are easily seen as different colours.