Following surgery, some patients experience a broken bone around the implants of a total hip replacement—called a periprosthetic femoral fracture. In a study of such patients published in the Journal of Bone and Mineral Research, investigators found that 8.3% of patients had atypical femoral fractures, which are a rare type of femoral stress fracture. The researchers also found a strong association between use of bisphosphonates and risk of atypical femoral fractures.
Previous studies have linked bisphosphonates use to atypical femoral fractures in patients with osteoporosis. However, these are very rare events, which are overwhelmed by the fracture prevention effect of bisphosphonates.
“Fractures around orthopedic implants are becoming increasingly more frequent. Our work shines light on the necessity for clinicians to better identify this subgroup of patients with atypical fractures around a femoral implant as they may benefit from different therapies,” said senior author Dr. Etienne Belzile, of CHU de Québec – Université Laval, in Canada.
Link to Study: https://onlinelibrary.wiley.com/doi/10.1002/jbmr.3584
The Journal of Bone and Mineral Research (JBMR) publishes highly competitive original manuscripts, reviews, and special articles in basic and clinical science relevant to bone, muscle and mineral metabolism. Manuscripts are published on the biology and physiology of bone and muscle, relevant systems biology topics (e.g. osteoimmunology), and the pathophysiology and treatment of sarcopenia and disorders of bone and mineral metabolism. JBMR is the official journal of the American Society for Bone and Mineral Research (ASBMR), published monthly on the Society’s behalf by Wiley-Blackwell. With an impact factor of 6.314, JBMR is the top-ranked journal in its field.
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