11:00pm Thursday 14 December 2017

Osteoporosis : balancing bone formation and degradation

Researchers from the CNRS, Inserm and the Université de Montpellier and Université Jean Monnet – Saint-Étienne1 have developed a new approach for preventing the destructive activity of osteoclasts without affecting their viability. This involves disrupting their anchorage to the bone, which has been found to be possible using a small chemical compound called C21. This innovative treatment can protect mice from bone loss associated with osteolytic diseases2 such as post-menopausal osteoporosis, rheumatoid arthritis and bone metastasis, without affecting bone formation. This research was published on 3 February 2015 in the journal Nature Communications.

To download the press release: Ostéoporose

Notes:

1From the Centre de recherche de biochimie macromoléculaire (CRBM) [Centre for Biochemical and Macromolecular Research] (CNRS/Université de Montpellier), Laboratoire d’enzymologie et biochimie structurale (LEBS) [Laboratory of Enzymology and Structural Biochemistry] (CNRS), Institut de recherche en cancérologie de Montpellier (IRCM) [Montpellier Cancer Research Institute] (Inserm/ Université de Montpellier) and Laboratoire de biologie intégrative du tissu osseux [Laboratory of integrative biology of bone tissue] (Inserm/Université Jean Monnet – Saint-Étienne).
2Diseases related to the degradation of bone tissue.

References:

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation. Virginie Vives, Gaëlle Cres, Christian Richard, Muriel Busson, Yann Ferrandez, Anne-Gaelle Planson, Mahel Zeghouf, Jacqueline Cherfils, Luc Malaval and Anne Blangy. Nature communications, 3 February 2015. DOI: 10.1038/ncomms7218.

Contact information:

CNRS Researcher l Anne Blangy l T +33 (0)4 34 35 95 08 l anne.blangy@crbm.cnrs.fr
CNRS Press l Alexiane Agullo l T +33 (0)1 44 96 43 90 l alexiane.agullo@cnrs-dir.fr


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