The findings suggest that there may be a way to promote survival of neurons by helping a beneficial protein linger a little longer inside nerve cells. Patients with SMA gradually lose the motor neurons in the spine that control most of their muscles. Researchers have known since the 1990s that the disease is nearly always linked to the absence or disruption of a gene known as SMN1 (Survival of Motor Neuron 1). A nearby gene, SMN2, is virtually identical to SMN1, and in principle could produce enough SMN protein to keep neurons healthy – yet somehow fails to do so. The findings appear in the March issue of Genes & Development.
For more, read the HHMI summary at http://www.hhmi.org/news/dreyfuss20100301.html
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