“We think brain cells might be trapped while in the process of migrating to the cortex while the brain develops. This process of neuronal migration to the cortex doesn’t stop at birth. It’s robust in infants and may continue in teenage years and beyond,” she says.
“We know that brain development is derailed somehow in people with schizophrenia, and this study helps us understand how,” says Professor Shannon Weickert.
The next step is to understand why these neurons are failing to complete their journey to the cortex.
“Then maybe we can develop a therapy that encourages the neurons to keep moving to the finish line. Our hope is that this would reduce symptoms or even prevent schizophrenia from developing at all.”
The paper is published in the journal Biological Psychiatry.
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