The Effect Of Ibuprofen On The Nervous System – Uses & Side Effects

The popular pain-relieving medication ibuprofen plays a job in our nervous system. For the primary time, researches from the University of Copenhagen have currently been able to determine how the drug works within the nervous system. The researchers hope this new information will contribute to the production of higher and more targeted pain-relieving medication in the future.

Ibuprofen also referred to as the drugs Ipren, Ibumetin, and Brufen, could be a pain-relieving drug (NSAID) used for treating fever, pain, and inflammation. But ibuprofen also plays a task in our nervous system, as the drug also can be used to treat pain caused by acid damage and to protect against certain varieties of brain damage caused by stroke. Previous studies have shown that this is because of ibuprofen’s interaction with a particular receptor – the so-called acid receptor – within the nervous system. However, the character of this interaction has so far been unknown.

For the first time, we are able to give a full image of how ibuprofen affects the acid receptor in the nervous system. We have examined in additional detail the acid receptor that’s activated each time we feel pain or just in case of cell death, e.g. following a stroke. Through research, it was discovered that receptor changes shape that prevents the message of having pain being sent to the brain. This study was conducted by Prof. Stephan Alexander Pless from the Department of Drug Design and Pharmacology.

Benefits of Ibuprofen

Ibuprofen is used to treat pain from numerous conditions like headaches, dental pain, menstrual cramps, muscle aches, or inflammatory disease. A study about it proves that it is also used to reduce fever and to relieve minor aches and pain due to the common cold or flu. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of sure natural substances that cause inflammation. This impact helps to decrease swelling, pain, or fever.

If you’re treating a chronic condition like inflammatory disease, ask your doctor concerning non-drug treatments and/or using different medications to treat your pain. Also, check the warning section.

Check the ingredients on the label even if you have used the merchandise before. The manufacturer could have modified the ingredients. Also, products with similar names may contain completely different ingredients meant for different purposes. Taking the wrong product may hurt you.

The Discovery Will Help Target Drugs in the Future

The researchers hope their discovery will help target and refine the development of pain-relieving drugs in the future.

As researchers, we are constantly trying to learn and gain new knowledge of drugs and their effects. ibuprofen is a medication employed by many people, and that we are therefore fascinated by getting the complete picture of how it affects the body. For the first time, we now have detailed knowledge of how it works, and naturally, we hope others will be able to use this knowledge constructively in the future to develop new and more targeted drugs’, says Stephan Pless.

New Technique Helps the Researchers Establish the Effect of Ibuprofen

With a view to establishing the impact of ibuprofen on the nervous system, the researchers created a series of slightly totally different versions of the acid receptor. Here they examined the activity within the cell before and after adding ibuprofen and minutely elaborate the interaction. In the process, they had to use a new method involving fluorescent substances, as the receptors are so small that they’re invisible to the eye. But using the fluorescent technique, that makes the receptors light up, the researchers have gained further insight into the process and also the movement of the receptors.

The researchers discovered that the impact of ibuprofen is caused by the receptor taking on a brand new kind. Usually, the receptor takes on a special type, which the cell acknowledges as pain-inducing. Then the cell transmits signals to the brain and pain is sensed. If ibuprofen is added, however, the receptor takes on a unique form. This implies that the cell is unable to recognize it as pain-inducing and therefore fails to send signals to the brain.

How to use Ibuprofen

If you’re taking the over-the-counter product, browse all directions on the product package before taking this medication. If your doctor has prescribed this medication, scan the Medication Guide provided by your pharmacist before you begin taking ibuprofen and every time you get a refill. If you’ve got any queries, ask your doctor or pharmacist.

Several people may take this medication orally, typically each four to six hours with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Don’t lie down for a minimum of 10 minutes when taking this drug. If you have an upset stomach while taking this medication, take it with food, milk, or an antacid may help.

The dose relies on your medical condition and response to treatment. to cut back your risk of stomach injury and different side effects, take this medication at the lowest effective dose for the shortest potential time. Do not raise your dose or take this drug more typically than directed by your doctor or the package label. For current conditions like inflammatory disease, continue taking this medication as directed by your doctor.

When ibuprofen is employed by youngsters, the dose would depend on the child’s weight. Check the package directions to find the right dose for your child’s weight. Consult the pharmacist or doctor if you’ve questions or if you would like help selecting a nonprescription product.

For certain conditions (such as inflammation), it’s going to take up to 2 weeks of taking this drug frequently till you get the total benefit. If you’re taking this drug “as needed” (not on a daily schedule), keep in mind that pain medications work best if they’re used as the first signs of pain occur. If you wait until the pain has worsened, the medication might not work as well.

If your condition persists or worsens, or if you’re thinking that you may have a serious medical problem, get medical help quickly. If you’re using the nonprescription product to treat yourself or a child for fever or pain, consult the doctor directly if fever worsens or lasts over three days, or if pain worsens or lasts more than 10 days.

Interactions with Ibuprofen

Medicines that interact with ibuprofen might either decrease its effect, have an effect on how long it works for, increase side effects, or have less of an effect when taken with ibuprofen. An interaction between two medications doesn’t always mean that you should stop taking one of the medications; however, generally, it will. Speak to your doctor regarding how drug interactions should be managed.

Common medications that may interact with ibuprofen include:

  • ACE inhibitors or ARBs, such as captopril, enalapril, or losartan
  • Antibiotics, such as ciprofloxacin or vancomycin
  • Anticoagulants (blood thinners) such as apixaban, dabigatran, fondaparinux, heparin, or warfarin
  • Antidepressants, such as citalopram, escitalopram, fluoxetine, or paroxetine
  • Antifungals, such as voriconazole
  • Antiplatelets, such as clopidogrel or ticagrelor
  • Beta-blockers, such as acebutolol, atenolol, bisoprolol, or carvedilol
  • Bisphosphonates, such as alendronate
  • Corticosteroids, such as dexamethasone or prednisone
  • Digoxin
  • Diuretics (water pills), such as chlorthalidone, chlorothiazide, hydrochlorothiazide (HCTZ), or furosemide
  • Glucagon
  • Haloperidol
  • HIV medications (eg, Stribild, tenofovir)
  • Metformin
  • Other nonsteroidal anti-inflammatories (NSAIDs), such as celecoxib, diclofenac, etodolac, ketorolac, meloxicam, nabumetone, or naproxen
  • Sulfonylureas (a type of diabetes medication), such as glimepiride, glyburide, or glipizide
  • Supplements, such as glucosamine, omega-3 fatty acids, vitamin E
  • Others, such as cyclosporine, lithium, methotrexate, pemetrexed, pirfenidone, or tacrolimus.
  • Drinking alcohol while taking ibuprofen may increase the risk of gastrointestinal-related side effects or kidney damage.

Note that this list is not all-inclusive and includes only common medications that may interact with ibuprofen. You should refer to the prescribing information for ibuprofen for a complete list of interactions.

Precautions 

Before taking ibuprofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Kidney problems will generally occur with the use of anti-inflammatory medications, as well as ibuprofen. Problems are more likely to occur if you’re dehydrated, have heart disease or kidney disease, are an older adult, or if you take certain medications. Drink lots of fluids as directed by your doctor to stop dehydration and tell your doctor directly if you have got a change in the amount of urine.

This drug may make you dizzy or drowsy. Alcohol or marijuana will make you more dizzy or drowsy. Don’t drive, use machinery, or do anything that wants alertness until you’ll do it safely. Limit alcoholic beverages. Discuss with your doctor if you’re using marijuana.

This medicine may cause stomach bleeding. Regular use of alcohol and tobacco, particularly when mixed with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Ask your doctor or pharmacist for additional information.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older people may be at greater risk for stomach/intestinal bleeding, kidney problems, heart attack, and stroke while using this drug.

Before using this medication, women of childbearing age are required to speak with their doctor(s) regarding the advantages and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you’re pregnant or if you intend to become pregnant. During pregnancy, this medication must be used only if required. It is not suggested for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

This medication passes into breast milk yet it is unlikely to harm a nursing infant. Ask your doctor before breast-feeding.

Resources

pubmed.ncbi.nlm.nih.gov