Spinal cord injury affects the heart, that’s what research published in Experimental Physiology and carried out by researchers from University of British Columbia, Canada has found.
The heart undergoes changes after spinal cord injury that are dependent on how severe the spinal cord injury is but only a small amount of “sparing” (i.e., a small number of nerve fibers preserved) in the spinal cord are necessary for the heart to function at a near normal level.
This research has important clinical implications as one of the primary aims of spinal cord injury management is to reduce the amount of damage that happens after the initial trauma. This exacerbation of the primary injury is termed the “secondary injury”, and is driven by complex cellular processes that eventually result in the ‘size’ of the injury enlarging and therefore damaging more nerve fibres. These findings imply that if more nerve fibers can be preserved following spinal cord injury (for example by reducing the extent of the secondary injury), then there could be improvements in how the heart functions. This is important as individuals with spinal cord injury are at a much higher risk for heart disease than people without spinal cord injury.
The research was carried out by comparing two different severities of spinal cord injury in a clinically-relevant rodent model. This rodent model was used because it allowed the researchers to carefully control the amount of damage to the spinal cord during the injury and definitively assess heart function as well as examine how the cells in the heart change. Studies that enable the underlying mechanisms of heart function to be examined after spinal cord injury are simply not possible in humans but by closely mimicking the injuries that occur in humans the findings are more readily able to be transferred to humans.
- The research was carried out by Dr. Christopher West, an assistant professor of Kinesiology at UBC and researcher with the ICORD spinal cord injury research centre. Dr. West and his colleagues compared two different severities of spinal cord injury in a clinically-relevant rodent model.
- Spinal cord injury induced cardiomyocyte atrophy and impaired cardiac function are severity dependent: http://onlinelibrary.wiley.com/doi/10.1113/EP086549/full (before the embargo date, please email for a copy of the paper)
- Experimental Physiology publishes advances in physiology which increase our understanding of how our bodies function in health and disease. http://ep.physoc.org
- The Physiological Society brings together over 3,500 scientists from over 60 countries. The Society promotes physiology with the public and parliament alike. It supports physiologists by organising world-class conferences and offering grants for research and also publishes the latest developments in the field in its three leading scientific journals, The Journal of Physiology, Experimental Physiology and Physiological Reports. www.physoc.org
University of British Columbia, Canada