Key to brain cell communication is like oil and water

Updated on - Written by

 

The nervous system depends upon the tightly regulated spatial and temporal communication that occurs between neurons at specialized connections called synapses. Chemical signals called neurotransmitters, the molecules responsible for communication between neurons, are packed into hundreds of membrane sacks known as synaptic vesicles. These vesicles form tight clusters at the nerve terminal. Despite being held together, vesicles are highly mobile within these clusters, so that they can be randomly recruited to the surface of the cell to release their content upon activation of the neuron.

In a new paper published July 5 in the journal Science, Yale researchers describe how this compact but highly mobile structure is achieved. They found that synaptic vesicles organize themselves into a liquid compartment within interior of the cell, much as oil does when mixed with water. The new research shows groups of synaptic vesicles can “demix” in the presence of a common nerve terminal protein synapsin, explaining how vesicles can both remain tightly clustered yet rapidly fuse with membrane of neurons when activated, said Yale’s Dragomir Milovanovic, lead author of the study and postdoctoral researcher in the lab of Pietro De Camilli.

 

 Yale University

 


+ sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

Written by:

Healthcanal Staff

Medically reviewed by:

HealthCanal Editorial team is a team of high standard writers, who qualified the strict entrance test of Health Canal. The team involves in both topic researching and writting, which are under supervision and controlled by medical doctors of medical team.

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source