A study associates different clinical profiles in Huntington’s disease with two specific neural signatures


A new study has identified two specific patterns of brain alterations underlying two clinical disorders of Huntington’s disease, a progressive and irreversible neurodegenerative disease caused by the mutation of the gen that codes the huntingtin protein. The study, published in the journal NeuroImage: Clinical, is led by researchers Estela Càmara and Ruth de Diego, from the research group on Cognition and Brain Plasticity of the University of Barcelona and the Bellvitge Biomedical Research Institute (IDIBELL).

The new study could help develop specific biomarkers and customized treatments for each profile I this rare hereditary disease. This neurodegenerative disease is known for “creating motor, cognitive and psychiatric deficiencies, but there is a big heterogeneity regarding the symptoms among patients. Therefore, we decided to analyse the neurobiological bases of these differences to see whether we could like them to clinical profiles”, notes Ruth de Diego, from the Faculty of Psychology and the Institute of Neurosciences of the University of Barcelona (UBNeuro) and ICREA researcher.

Other participants in this study, whose first author is the researcher Clara García-Gorro (UB-IDIBELL), are experts from the University Hospital de Bellvitge, Hospital Santa Creu i Sant Pau, Hospital CLínic de Barcelona, Hospital Mare de Déu de la Mercè and Radboud University (the Netherlands), among other institutions.


Universitat de Barcelona