Prof Cyndi Shannon Weickert, Dr Dipesh Joshi and colleagues from Neuroscience Research Australia studied the brains of people with schizophrenia and focussed on one of the hardest-hit regions, the orbitofrontal cortex, which is the part of the brain involved in regulating emotional and social behaviour.
Most neurons – brain cells that transmit information – are found in tissue near the surface of the brain. However, in the brains of people with schizophrenia, the team found a high density of neurons in deeper areas.
“For over a decade we’ve known about the high density of neurons in deeper brain tissue in people with schizophrenia. Researchers thought these neurons were simply forgotten by the brain, and somehow didn’t die off like they do during development in healthy people,” says Prof Shannon Weickert.
“What we now have is evidence that suggests these neurons are derived from the part of the brain that produces new neurons, and that they may be in the process of moving. We can’t be sure where they are moving to, but given their location it is likely they are on their way to the surface of the brain, the area most affected by schizophrenia,” Prof Shannon Weickert concluded.
Prof Cyndi Shannon Weickert is the Macquarie Group Foundation Chair of Schizophrenia Research, a joint venture of Neuroscience Research Australia, University of New South Wales, Schizophrenia Research Institute and Macquarie Group Foundation, and supported by NSW Health.
This paper is published in the journal Biological Psychiatry (attached to this email). If you would like more information or to interview Prof Shannon Weickert please call Ben Bravery at the NeuRA Media Office on +61 406 599 569.
How was this study done?
1. Brain tissue from the orbitofrontal cortex from 38 people with schizophrenia and 38 people without the disease were used in this study.
2. The density of interstitial neurons in the white matter, and the density of GABAergic neurons in the grey matter were measured.
3. An increased density of interstitial white matter neurons in the white matter, and decreased density of GABAergic neurons in the grey matter was found.
4. This pattern suggests that the migration of interstitial white matter neurons towards an area where they are lacking, because of schizophrenia, is a response to the disease.
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