06:04pm Friday 20 September 2019

Mapping the human brain

Neurosurgeon Charlie Teo, who is a senior lecturer at UNSW, and stem cell researcher Associate Professor Kuldip Sidhu have been chosen to address the Congress as part of Brain Mapping Day on 10 May.

Dr Teo will call for brain cancer research to be made part of President Obama’s $100 million plan to better understand the human brain.

“[Brain cancer] kills more kids than any other cancer and has more financial impact on America and every other country than any other cancer,” Dr Teo, the founder of the Cure for Life Foundation, told the Sydney Morning Herald.

Associate Professor Kuldip Sidhu, who is working on neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, will speak about the importance of patient-derived human stem cells as an platform to better understand disease processes with the potential for drug discovery and brain therapeutics.

This type of work is a step toward personalised medicine, with researchers collecting cells from patients with these diseases, investigating signs of the condition in cells and testing how they respond to drug treatments.

“Patient-derived stem cells will bring about a paradigm shift in human medicine,” says Professor Sidhu, who is part of UNSW’s Centre for Healthy Brain Ageing. “We will be able to translate research from the lab to the clinic faster and the outcomes will be better for patients.”

Professor Sidhu has called for such studies to be an integral part of President Obama’s plan to map the human brain and to be appropriately funded.

President Obama’s plan is seen as the brain’s equivalent of the human genome project, which sequenced the building blocks of DNA, and has delivered significant research benefits.

The initiative could lead to the creation of a map of the brain’s functional circuitry. By understanding how information in the brain is stored, retrieved and used, scientists will hope to gain insights into brain diseases.

Professor Sidhu earlier produced human embryonic stem cell lines at the Prince of Wales Hospital. One of these lines, Endeavour-2 is being used by the National Institutes of Health in the US.

Media contact: Susi Hamilton, UNSW media, 0422 934 024

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