02:18am Monday 17 February 2020

Penn Research Helps Identify New Brain Cell Involved in Navigation

The “grid cell,” which derives its name from the triangular grid pattern in which the cell activates during navigation, is distinct among brain cells because its activation represents multiple spatial locations. This behavior is how grid cells allow the brain to keep track of navigational cues such as how far you are from a starting point or your last turn. This type of navigation is called path integration.

The research was led by Michael Kahana, a professor of psychology in Penn’s School of Arts and Sciences, and his former graduate student Joshua Jacobs, now an assistant professor in Drexel’s School of Biomedical Engineering, Science and Health Systems, along with Itzhak Fried, professor of neurosurgery at the David Geffen School of Medicine at UCLA.

Their study was published in the journal Nature Neuroscience.

“It is critical that this grid pattern is so consistent because it shows how people can keep track of their location even in new environments with inconsistent layouts,” Jacobs said.

The researchers were able to discern these cells because they had the rare opportunity to study brain recordings of epilepsy patients with electrodes implanted deep inside their brains as part of their treatment.

During brain recording, the 14 study participants played a video game that challenged them to navigate from one point to another to retrieve objects and then recall how to get back to the places where each object was located. The participants used a joystick to ride a virtual bicycle across a wide-open terrain displayed on a laptop by their hospital beds. After participants made trial runs where each of the objects was visible in the distance, they were put back at the center of the map and the objects were made invisible until the bicycle was right in front of them. The researchers then asked the participants to travel to particular objects in different sequences.

The team studied the relation between how the participants navigated in the video game and the activity of individual neurons. 

“Each grid cell responds at multiple spatial locations that are arranged in the shape of a grid,” Jacobs said. “This triangular grid pattern thus appears to be a brain pattern that plays a fundamental role in navigation. Without grid cells, it is likely that humans would frequently get lost or have to navigate based only on landmarks. Grid cells are thus critical for maintaining a sense of location in an environment.”

These cells are not unique among animals — they have been discovered previously in rats ­­— and a 2010 study that used noninvasive brain imaging suggested the existence of the cells in humans. But this is the first positive identification of the human version of these cells.

“The present finding of grid cells in the human brain, together with the earlier discovery of human hippocampal ‘place cells,’ which fire at single locations, provide compelling evidence for a common mapping and navigational system preserved across humans and lower animals,” Kahana said.

The team’s findings also suggest that these grid patterns may in fact be more prevalent in humans than rats because the study found grid cells not only in the entorhinal cortex, where they are observed in rats, but also in a very different brain area, the cingulate cortex.

“Grid cells are found in a critical location in the human memory system called the entorhinal cortex,” Fried said. “This discovery sheds new light on a region of the brain that is the first to be affected in Alzheimer’s disease with devastating effects on memory”

The entorhinal cortex is part of the brain that has been studied in Alzheimer’s disease research and, according to Jacobs, understanding grid cells could help researchers understand why people with the disease often become disoriented. It could also help them show how to improve brain function in people suffering from Alzheimer’s.

The research was supported by the National Institutes of Health.

Christoph T. Weidemann of Swansea University, Jonathan F. Miller of Drexel, Alec Solway of Princeton University, John F. Burke and Xue-Xin Wei of Penn, Nanthia Suthana of UCLA and Michael R. Sperling and Ashwini D. Sharan of Jefferson also contributed to the study.

Media Contact:Katherine Unger Baillie | kbaillie@upenn.edu | 215-898-9194

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