Can Mild Hypothermia Treatment Improve Neuron Survival After Traumatic Brain Injury?

The article is available free on the Therapeutic Hypothermia and Temperature Management website.

The article “Effects of Mild Hypothermia Treatment on Rat Hippocampal β-Amyloid Expression Following Traumatic Brain Injury” coauthored by Shi-Xiang Cheng, Sai Zhang, Hong-Tao Sun, and Yue Tu, Logistics College of the Chinese People’s Armed Police Forces, Tianjin, China, is part of a special issue of Therapeutic Hypothermia and Temperature Management highlighting research conducted in China. Ji-Yao Jiang, PhD, MD, Jiaotong University School of Medicine, Shanghai, is Guest Editor of the special issue.

Cheng et al. compared the effects of normal temperature and hypothermia on rats with TBI. The animals treated with hypothermia had significantly improved behavioral scores and a greater number of surviving neurons compared to the normothermia group. The hypothermia-treated group also had significantly reduced levels of proteins that are produced by hippocampal tissue in the brain following TBI and that have been linked to increased severity of brain injury and subsequent cognitive dysfunction and possibly central nervous system disorders.

“This interesting manuscript provides new information underlying the beneficial effects of mild hypothermia on cellular responses to TBI and identifies an important target for therapeutic treatments,” says W. Dalton Dietrich, III, PhD, Editor-in-Chief of the Journal and Kinetic Concepts Distinguished Chair in Neurosurgery, Professor of Neurological Surgery, Neurology and Cell Biology, University of Miami Leonard M. Miller School of Medicine.

About the Journal
Therapeutic Hypothermia and Temperature Management provides a strong multidisciplinary forum to advance the understanding of therapeutic hypothermia. Novel findings from translational preclinical investigations as well as clinical studies and are featured in articles, state-of-the-art reviews, provocative roundtable discussions, clinical protocols, and best practices. Therapeutic Hypothermia and Temperature Management is the journal of record, published online with Open Access options and in print. Tables of content and a sample issue may be viewed on the Therapeutic Hypothermia and Temperature Management website.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Journal of Neurotrauma. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.