Or was that yesterday? Very often, our memories must distinguish not just what happened and where, but when an event occurred — and what came before and after. New research from the University of California, Davis, Center for Neuroscience shows that a part of the brain called the hippocampus stores memories by their “temporal context” — what happened before, and what came after.
“We need to remember not just what happened, but when,” said graduate student Liang-Tien (Frank) Hsieh, first author on the paper published March 5 in the journal Neuron.
The hippocampus is thought to be involved in forming memories. But it’s not clear whether the hippocampus stores representations of specific objects, or if it represents them in context.
Hsieh and Charan Ranganath, professor in the Department of Psychology and the Center for Neuroscience, looked for hippocampus activity linked to particular memories. First, they showed volunteers a series of pictures of animals and objects. Then they scanned the volunteers’ brains as they showed them the same series again, with questions such as, “is this alive?” or “does this generate heat?”
The questions prompted the volunteers to search their memories for information. When the images were shown in the same sequence as before, the volunteers could anticipate the next image, making for a faster response.
From brain scans of the hippocampus as the volunteers were answering questions, Hsieh and Ranganath could identify patterns of activity specific to each image. But when they showed the volunteers the same images in a different sequence, they got different patterns of activity.
In other words, the coding of the memory in the hippocampus was dependent on its context, not just on content.
“It turns out that when you take the image out of sequence, the pattern disappears,” Ranganath said. “For the hippocampus, context is critical, not content, and it’s fairly unique in how it pulls things together.”
Other parts of the brain store memories of objects that are independent of their context, Ranganath noted.
“For patients with memory problems this is a big deal,” Ranganath said. “It’s not just something that’s useful in understanding healthy memory, but allows us to understand and intervene in memory problems.”
Co-authors on the paper are Matthias Gruber and Lucas Jenkins, both at the UC Davis Center for Neuroscience. The work was partly supported by the National Institutes of Health, a Guggenheim Foundation fellowship to Ranganath, and a Howard Hughes Medical Institute fellowship awarded to Hsieh.
About UC Davis
For more than 100 years, UC Davis has been one place where people are bettering humanity and our natural world while seeking solutions to some of our most pressing challenges. Located near the state capital, UC Davis has more than 33,000 students, over 2,500 faculty and more than 21,000 staff, an annual research budget of over $750 million, a comprehensive health system and 13 specialized research centers. The university offers interdisciplinary graduate study and more than 100 undergraduate majors in four colleges — Agricultural and Environmental Sciences, Biological Sciences, Engineering, and Letters and Science. It also houses six professional schools — Education, Law, Management, Medicine, Veterinary Medicine and the Betty Irene Moore School of Nursing.
- Frank Hsieh, Psychology, Center for Neuroscience, [email protected]
- Charan Ranganath, Center for Neuroscience, [email protected] (Ranganath is currently on sabbatical at Cambridge University, England.)
- Andy Fell, UC Davis News Service, (530) 752-4533, [email protected]