01:46pm Sunday 20 August 2017

Cognitive abilities age at different rates as our brains get older

This challenges the previously held idea that, as we get older, these types of mental abilities all decline at the same rate. Given the number of people who are now living well into old age, this has important implications for our understanding of declining mental ability.

Skills such as understanding a new utilities bill or planning a shopping trip depend on relatively high-level cognitive abilities, or ‘executive functions’. As we grow older, our ability to perform executive functions declines more swiftly than that required to perform more simple or repetitive tasks, such as making a cup of tea or taking a familiar route to the shops.

Executive functions are associated with the frontal lobe of the brain, especially the prefrontal cortex. This area is known to deteriorate relatively rapidly in old age and scientists previously thought that all executive functions became impaired at roughly the same rate as this part of the brain degenerated. But the new research shows that this view is far too simplistic.

The study, part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initiative funded by BBSRC, identified two distinct cognitive skills associated with distinct regions of the brain: multi-tasking (the ability to perform more than one task simultaneously); and fluid intelligence (the ability to problem-solve, as measured in typical IQ tests for example).

It found that deterioration of these high-level functions occurred at different rates in different people and that the ability to problem-solve was more likely to be affected by age. These differences appeared closely linked tothe fact that their brains were aging differently. Importantly, the ability to problem-solve was more likely to be affected by age, whereas multi-tasking ability was more likely to be preserved.

Deterioration of the prefrontal cortex can be measured in many ways, for example in terms of loss of grey matter (containing the bodies of the brain’s cells) and white matter (containing the pathways that allow cells in different parts of the brain to communicate), and also in terms of different sub-regions within the prefrontal cortex.

By using a unique dataset of different cognitive tests and measuring multiple types of brain tissue in specific parts of the brain from nearly 600 individuals aged between 18 and 88, Dr Rogier Kievit and colleagues at the MRC Cognition and Brain Sciences Unit and the University of Cambridge, found that different parts and properties of the front of the brain supported problem solving and multi-tasking. The different brain regions (both white and grey matter) played specific and complementary roles in supporting these distinct functions, and aged at different rates, with white matter connections being more likely to be affected by age.

Dr Rogier Kievit said: “These results demonstrate that ageing, even for cognitive abilities that seem similar, is a far more multifaceted process than commonly thought.

“It’s crucial that we understand the role that different types of brain tissue play in cognition, especially in ageing brains, as we know from other research that lifestyle factors – such as exercise – can have different effects on white and grey matter. Knowing more about the neurological basis of age-related differences in people’s mental abilities might help us identify what factors are most likely to contribute to greater independence and a better quality of life for older people.”



Notes to editors


Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking by Kievit, R. A., Davis, S. W., Mitchell, D. J., Taylor, J. R., Duncan, J., Cam-CAN, & Henson, R. N. A. (2014) is published in Nature Communications.


Further information, copies of the paper and interviews with Dr Rogier Kievit available via the MRC Press Office (see external contact below).


About MRC


The Medical Research Council has been at the forefront of scientific discovery to improve human health. Founded in 1913 to tackle tuberculosis, the MRC now invests taxpayers’ money in some of the best medical research in the world across every area of health. Thirty MRC-funded researchers have won Nobel prizes in a wide range of disciplines, and MRC scientists have been behind such diverse discoveries as vitamins, the structure of DNA and the link between smoking and cancer, as well as achievements such as pioneering the use of randomised controlled trials, the invention of MRI scanning, and the development of a group of antibodies used in the making of some of the most successful drugs ever developed. Today, MRC-funded scientists tackle some of the greatest health problems facing humanity in the 21st century, from the rising tide of chronic diseases associated with ageing to the threats posed by rapidly mutating micro-organisms. www.mrc.ac.uk


About Cam-CAN


The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) is a large-scale collaborative research project, launched in October 2010, with substantial funding from the Biotechnology and Biological Sciences Research Council (BBSRC). Combining expertise from multiple fields, over 30 researchers, collaborators and their teams from the Departments of Psychology, Public Health and Primary Care, Psychiatry, Clinical Neurosciences, and Engineering in the University of Cambridge and the Medical Research Council Cognition and Brain Sciences Unit are working together examine key research questions about lifelong health and development, aiming to understand how individuals can best retain cognitive abilities into old age. Cam-CAN includes a large population-based sample of adults aged 18-88yrs, and uses a unique and powerful approach which integrates multiple domains including epidemiology, cognitive psychology, and neuroimaging. The research aims to understand brain-cognition relationships across the lifespan and how these impact on cognitive function, to determine the extent of neural flexibility and the potential for neural reorganisation to preserve cognitive functions and, crucially, to change the perspective of ageing in the 21st century by highlighting the importance of abilities that are maintained into old age. www.cam-can.com

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