01:28am Monday 18 December 2017

Focal Epileptic Seizures Linked to Abnormalities in Three Main Brain Regions

Seizures in people with focal epilepsy can originate in various sites in the brain, but these new findings link those sites to three main brain regions, as reported in Brain Connectivity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available to download for free on the Brain Connectivity website until December 25, 2015.

In the article “Abnormal Brain Areas Common to the Focal Epilepsies: Multivariate Pattern Analysis of fMRI,” the authors propose that “these brain areas may represent key regional network properties underlying focal epilepsy.”

Mangor Pedersen and coauthors from The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, and Austin Health, Melbourne, Australia, combined three distinct but complementary fMRI measures to distinguish alterations in brain activity and the interaction between brain regions. They found abnormalities in the ipsilateral piriform cortex, temporal neocortex, and ventromedial prefrontal cortex in individuals with focal epilepsy. In addition, the researchers showed additional effects in the insula and frontal cortex and the ipsilateral thalamus/striatum.

“Focal epilepsy is a diverse neurological condition with seizures emanating from different brain areas depending on the individual patient,” says Christopher Pawela, PhD, Co-Editor-in-Chief of Brain Connectivity and Assistant Professor, Medical College of Wisconsin. “Pedersen and colleagues were able to identify common brain regions affected in all focal epilepsy patients. Further, they were able to accurately separate epilepsy patients from healthy controls using pattern matching analysis which may be an important step towards developing a MR biomarker for the condition.”

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About the Journal
Brain Connectivity is the essential peer-reviewed journal covering groundbreaking findings in the rapidly advancing field of connectivity research at the systems and network levels. Published 10 times per year in print and online, the Journal is under the leadership of Founding and Co-Editors-in-Chief Christopher Pawela, PhD, Assistant Professor, Medical College of Wisconsin, and Bharat Biswal, PhD, Professor of Biomedical Engineering, New Jersey Institute of Technology. It includes original peer-reviewed papers, review articles, point-counterpoint discussions on controversies in the field, and a product/technology review section. To ensure that scientific findings are rapidly disseminated, articles are published Instant Online within 72 hours of acceptance, with fully typeset, fast-track publication within 4 weeks. Tables of content and a sample issue may be viewed on the Brain Connectivity website.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative medical and biomedical peer-reviewed journals, including Journal of Neurotrauma and Therapeutic Hypothermia and Temperature Management. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website.


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