01:51am Thursday 14 November 2019

Ultra wide-angle imaging may help uncover link between Alzheimer’s Disease and AMD

Researchers from University College of London, Moorfields Eye Hospital, the West London Mental Health Trust and Imperial College London took color and autofluorescence (AF) images using an Optos P200C AF ultra-wide angle laser scanning ophthalmoscope (200°) to determine the phenotypic variation in the macula and the periphery in 56 Alzheimer’s dementia patient and 48 controls.

They will present their results at the 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology in Fort Lauderdale, Fla.

The researchers report that most patients had to be imaged through dilated pupils to achieve gradable images, while most controls needed no dilation. Of those with macular pathology, all but four had peripheral pathology such as drusen and retinal pigment epithelial changes (chi²=18.1; p<0.01).

They concluded: “The ultra-wide angle images revealed wide-ranging pathologies in the periphery, especially in the far periphery, in Alzheimer’s disease patients. The extent of peripheral pathology and the potential association with CFH genotype warrant further investigation to better understand the association between genotype and phenotype in relation to Alzheimer’s disease and AMD.”

Abstract title: The Association Between Alzheimer’s Disease and Age-Related Macular Degeneration: A Pilot Study Using Ultra-Wide Angle Imaging
Presentation start/end time:
Location: Hall A, Broward County Convention Center
Program No. 533

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The Association for Research in Vision and Ophthalmology (ARVO) is the largest eye and vision research organization in the world. Members include more than 12,500 eye and vision researchers from over 80 countries. ARVO encourages and assists research, training, publication and knowledge-sharing in vision and ophthalmology. For more information, visit www.arvo.org

All abstracts accepted for presentation at the ARVO Annual Meeting represent previously unpublished data and conclusions. This research may be proprietary or may have been submitted for journal publication. Embargo policy: Journalists must seek approval from the presenter(s) before reporting data from paper or poster presentations. Press releases or stories on information presented at the ARVO Annual Meeting may not be released or published until the conclusion of the presentation.

Media Contact:
Jo Olson

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