Researchers from University College of London, Moorfields Eye Hospital, the West London Mental Health Trust and Imperial College London took color and autofluorescence (AF) images using an Optos P200C AF ultra-wide angle laser scanning ophthalmoscope (200°) to determine the phenotypic variation in the macula and the periphery in 56 Alzheimer’s dementia patient and 48 controls.
They will present their results at the 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology in Fort Lauderdale, Fla.
The researchers report that most patients had to be imaged through dilated pupils to achieve gradable images, while most controls needed no dilation. Of those with macular pathology, all but four had peripheral pathology such as drusen and retinal pigment epithelial changes (chi²=18.1; p<0.01).
They concluded: “The ultra-wide angle images revealed wide-ranging pathologies in the periphery, especially in the far periphery, in Alzheimer’s disease patients. The extent of peripheral pathology and the potential association with CFH genotype warrant further investigation to better understand the association between genotype and phenotype in relation to Alzheimer’s disease and AMD.”
Abstract title: The Association Between Alzheimer’s Disease and Age-Related Macular Degeneration: A Pilot Study Using Ultra-Wide Angle Imaging
Presentation start/end time:
Location: Hall A, Broward County Convention Center
Program No. 533
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