04:25pm Friday 05 June 2020

Some Ethnicities have a Greater Chance of Developing Alzheimer’s Disease before Age 65

We have been studying early-onset dementia for some years and have been limited by a small number of subjects in order to do proper analyses. We seized the opportunity to analyse statistics from the C-PATH Online Data Repository, which contains information of over 6500 subjects. Previous studies have suggested that certain ethnic minorities might be at risk from early-onset Alzheimer’s disease. Early-onset Alzheimer’s disease (onset before age 65 years) seems to be different from late-onset disease and occurs independent of hypertension, stroke and atrial fibrillation, factors important in old-onset disease. Our previous studies on small numbers urged us to confirm this in a larger dataset. We therefore looked at the analyses of 6500 subjects and observed that Native Americans, Alaskans and African-Americans seem to be at a greater risk of early-onset Alzheimer disease than other ethnicities.

Prof PK Panegyres and Dr HY Chen from Neurodegenerative Disorders Research Pty Ltd (Perth, Western Australia) analysed statistics from the C-PATH online data repository (CODR) and concluded that “ethnicity may impact on Alzheimer’s disease through age of onset, co-morbidities, family history, ApoE gene status and cognitive change over time. The greater odds of early-onset Alzheimer’s disease among African Americans, Alaskans and Hawaiians suggest that some ethnicities may be at risk of Alzheimer’s disease at a younger age.

Figure: The odds of EOAD estimated by logistic regression by ethnicity

HY Chen & PK Panegyres, “The Role of Ethnicity in Alzheimer’s Disease: Findings from the C-PATH Online Data Repository”, Journal of Alzheimer’s Disease, Volume 51, Issue 2 (March 2016) DOI 10.3233/JAD-151089.

Neurodegenerative Disorders Research Pty Ltd (NDR) is a research organisation devoted to the understanding of neurodegenerative disorders. NDR is a not-for-profit organisation, collaborating nationally and internationally. www.ndr.org.au

Professor Peter K. Panegyres, MD, PhD, FRACP
Neurodegenerative Disorders Research Pty Ltd
Ph: +618 9481 6293, [email protected]

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