Bipolar Disorder & Autism: Symptom Similarities, Differences

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Medically reviewed by Kimberly Langdon, MD

Bipolar Disorder & Autism: Symptom Similarities, Differences

Bipolar disorder (BD) and Autism spectrum disorder (ASD) both are brain disorders, but they have distinct characteristics which might overlap in some cases. ASD is essentially a developmental disorder. Bipolar disorder might or might not have a developmental connection.  

Bipolar disorder formerly called manic depression is characterized by severe mood swings, rapid changes in energy levels, and functioning. Whereas Autism is characterized by difficulty in speech, communication, social skills, and behavior. 

Can these two conditions co-exist? Do patients with ASD also suffer from bipolar disorder or vice versa? How to differentiate between the two conditions? In this article, we will answer all these questions along with the symptoms, similarities, and differences between the two conditions.

Is there a connection between Autism and Bipolar disorder? 

Some symptoms of bipolar disorder overlap with ASD but are there a real connection between the two? Research indicates that these two brain conditions share some gene expression patterns. But the presence of both the conditions together is not prevalent. According to one study, a significant minority of ASD patients also suffer from bipolar affective disorder. 

So, co-existence of the two conditions is possible but it doesn’t indicate that a person with ASD will also have bipolar disorder or vice versa. The similarity between the symptoms of the two conditions might make it difficult to diagnose and differentiate one from the other particularly if BD is apparent from childhood. 

Generally, red flags for autism are evident in the child before the appearance of bipolar disorder. In the case of pediatric bipolar disorder, the symptoms may become evident as early as 5 years of age of the child. 

That said, one study found, as much as 30% of youth with bipolar disorder also had ASD. Interestingly, BD appeared earlier in presence of ASD comorbidity.

 One gene sequencing study of bipolar disorder identified significant associations between the genes of autism and bipolar disorder indicating a genetic overlap which might also support the overlapping of the symptoms of the two conditions. Autism shares brain signature with both schizophrenia and bipolar disorder.    

The latest findings on the co-occurrence of the two conditions are disparate and demand more research to arrive at any conclusion. 

Bipolar disorder: Symptoms

Unusual mood and behavioral shifts which severely impact day to day life is the primary characteristic of bipolar disorder. It includes periods of extreme happiness, overexcitement, or overjoy termed as ‘manic episodes’ followed by periods of extreme hopelessness, sadness, and depression. 

The symptoms are much more severe than the normal ups and downs in the mood everyone goes through and can be easily distinguished by the sheer intensity of the episodes. Often, bipolar disorder appears during teenage or early adulthood but it might appear during childhood as well. 

The word ‘bipolar’ means two opposite poles because a person suffering from bipolar disorder experiences both the poles – the high experienced as ‘mania’ and the low experienced as ‘depression’ within minimum time.  

Symptoms of a typical manic episode  

  • Talking very fast 
  • Changing topics quickly 
  • Behaving impulsively 
  • Distracted and restless behavior 
  • Sleeping very little or not sleeping at all
  • Over energetic activity

Typical symptoms of a depressive episode

  • Feeling tired or low all the time 
  • Sleeping a lot 
  • An abrupt change in eating habits 
  • Irritability 
  • An intense feeling of hopelessness 
  • Suicidal thoughts and tendencies  

Autism: Symptoms

Autism on the other hand is characterized by symptoms like problems in social interaction, communication, inability to understand others’ feelings, jokes or sarcasm, compulsiveness in following a routine, hyperactivity, impulsivity, aggression, and temper tantrums

However, the severity of these symptoms varies considerably from person to person. Autism Spectrum Disorder covers a wide range of disorders under its umbrella and some symptoms can be specifically more or less intense, subdued or prominent in an individual. 

It is a developmental brain disorder and the symptoms are often evident by 1-3 years age of the child.  

Similarities and differences between bipolar disorder and autism

The overlapping symptoms that are generally present in people with bipolar disorder and also in people with ASDs include, 

  • Frequent episodes of elevated mood
  • High irritability 
  • Excessive activity
  • Disturbed sleep 
  • Repetitive behavior 
  • Distractibility and impulsivity  

However, if a person with ASD shows all or a few of the above symptoms it does not necessarily mean that the person also has bipolar disorder. Not surprisingly, the symptoms of bipolar disorder in someone with autism will appear much different than they would in a person not with ASD. If a person has both the conditions, the following symptoms are most likely to be noticed, 

  • Pressured speech defined as loud, rapid, and virtually nonstop speech   
  • Increased impulsivity leading to aggression  
  • An abrupt decrease in sleep 
  • Constant pacing

It is challenging to diagnose psychiatric disorders in children or adults having some kind of speech or communication impairment – which is the case with autism. According to the doctors working in this field, bipolar disorder is often over-diagnosed in people with autism as individuals with the condition find it difficult to understand the questions and express themselves properly.

The doctors found the symptoms of true bipolar disorder can be distinguished from autism by carefully observing when the symptoms appear and how long they last. If the presence of one symptom is evident, it is suggested to look out for the other symptoms before making the final diagnosis.   

Bipolar disorder – cause and treatment 

The exact cause for bipolar disorder is not known but there can be several related factors triggering the condition. According to experts, it may be caused due to some underlying problem in specific brain circuits and the functioning of the neurotransmitters

Classical genetic research indicates there is a strong contribution of genetic factors which are often inherited. Having a first-degree relative, a parent, or a sibling with the condition significantly increases the risk of the disorder.  


Antipsychotic drugs are used to treat the ‘mania episodes’ but their effectiveness in treating depression is variable. Antidepressants are widely used to manage ‘depressive episodes’ but their effectiveness and side effects remain uncertain and controversial. A combination of medication and psychosocial intervention can be effective for long-term maintenance and stabilization.     

Autism spectrum disorder – cause and treatment 

Both genetics and environment are supposed to play a role in the development of ASD. A number of genes associated with the condition have been identified. Research suggests that ASD could be a result of disruption of normal brain growth very early in the development. These disruptions might be caused by genetic factors.  

Environmental factors may also play a role but no specific cause has been identified yet. Research shows the risk of autism is higher in prematurely born children. Having an elder sibling with autism and exposure of the mother to cigarette smoke during pregnancy have also been linked to increased risk of autism in the child.  


Therapies and behavioral interventions designed to address the specific symptoms of the individual are effective for long-term management of the condition but there is no cure. Early educational intervention has been found effective in most cases. Medication can be used for treating symptoms like anxiety and depression.  


Both the conditions, bipolar disorder, and autism are brain disorders and have some overlapping symptoms. The two diseases have been found to share some particular brain signatures, so the relation is evident. Comorbid occurrence of the two conditions is not rare but that doesn’t mean an individual with ASD will also have bipolar disorder or vice versa. 

The exact causes for both these disorders are still not known but there are some risk factors that might contribute to the occurrence – genetics being one of the most important factors for both. However, as the symptoms of bipolar disorder are often expressed ‘differently’ in a person with ASD, it is important to conduct the diagnosis depending on multiple factors after long-term observation. 

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Written by:

Ananya Lahiri

Medically reviewed by:

Ananya Lahiri holds a Bachelor's degree in Life Sciences and a Master's degree in Bioinformatics. She is also the published author of several Health & Wellness blogs, guides, and e-books. With years of experience in the education and e-learning industry, she is keen on sharing information that can help people in making informed choices. Ananya is an avid dog lover with a specific interest in Huskies and GSDs. She is also a certified translator and holds a certificate in digital marketing. Apart from Health and Medical, Ananya also enjoys writing on tech, fashion, and beauty niches. She has crafted study materials for Cosmetology & Nursing courses.

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