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How Does CBD Help With Diabetic Nerve Pain?

Lakshmi Vemuri

Updated on - Written by
Medically reviewed by Kimberly Langdon, MD

CBD Help With Diabetic Nerve Pain

Dealing with diabetes can be a daunting task. It affects our overall immune system, causes inflammatory problems, and is also responsible for nerve pain. Diabetic Neuropathy, a condition diabetic patients may develop, causes serious pain in the legs and arms. And, there aren’t many treatments available for this condition. 

However, many researchers have found CBD for diabetic nerve pain to be an effective treatment method. If you are suffering from neuropathic pain, you must consider using CBD oil or CBD cream. If you are not sure how and why it works, continue reading to find out more. 

How does CBD work for Diabetes?

People with diabetes often suffer from many related ailments. Chronic pain and neuropathy in the feet and legs are one of the comorbidities a diabetic person goes through. To handle such pain, you might want to consider CBD products, as several studies have shown that CBD is effective[1] against neuropathic pain. Moreover, CBD oil helps in treating not only neuropathy but also several other diabetic symptoms as well.

CBD can help you cut down high blood sugar, bad cholesterol levels, and stimulates insulin production as well. By doing so, it can act as a supporting agent to you in managing diabetes. Here is how CBD works for diabetes

CBD for Diabetic Nerve Pain Relief

One of the most significant benefits of CBD is its pain-relieving properties. Most of the CBD products including CBD oils and CBD creams work well against peripheral neuropathy as well. If you are suffering from conditions such as diabetic neuropathy, CBD oil can save you from a lot of pain. Well, how does it work? 

First, you need to understand a bit about Diabetes and neuropathy. This health condition is inflammatory, and in turn, causes pain in several parts of your body. Researchers have shown that cannabinoids can suppress[2] inflammation and neuropathic pain. Cannabinoids, which are found in CBD, work on the core of the problem. They target the nerve endings, and by doing so, reduces pain and inflammation. Here’s a detailed breakdown of how CBD can aid you in pain management caused by type 1 or type 2 diabetes: 

CBD regulates pain signals:

CBD regulates pain and its sensation by stimulating the reabsorption of a neurotransmitter called Adenosine. This way, CBD helps enhance the adenosine levels in the brain and nervous system, which helps reduce pain caused by peripheral neuropathy. 

CBD might also help in blocking pain signals from reaching the pain processing centers in your brain. It does this by binding to TRPV1, a receptor responsible for inflammation and pain[3]

CBD enhances Immune response:

CBD may help in suppressing the levels of pro-inflammatory cytokines[4] as well. Additionally, it also plays a role in inhibiting the proliferation of T cells. By doing so, CBD helps in managing your immune response better to inflammation and neuropathy. 

CBD reduces inflammation:

CBD contains several anti-inflammatory and antioxidant properties[5], which help in reducing inflammation and oxidative stress. It may also decrease inflammation by balancing the levels of microelements such as selenium and zinc, which are highly essential for a balanced immune response. CBD oils can also help you counter neuropathic pain by regulating hyperalgesia, which is an abnormally increased pain response. 

CBD boosts your sleep and mood:

When you are suffering from diabetic neuropathy, the pain may cause you to lose sleep more often than not. And, when you do not get enough sleep, your immune system falls back, which in turn, may lead to more agony. 

Enhancing your sleep is one of the well-known effects of CBD. When suffering from diabetic neuropathy, it is common for you to feel fatigued and anxious as well. Cannabidiol CBD can help you manage these symptoms[6]. Particularly, full-spectrum CBD is known to immensely improve your sleep and mood.

CBD for Regulating Blood Sugar Levels

When you try to manage diabetes, it is important to manage blood glucose levels and cholesterol levels. CBD oil can help you regulate both those levels. Moreover, this mice study[7] has shown that cannabis has a significant role in reducing diabetic incidence. 

CBD oil is known to enhance insulin levels. Apart from that, it can activate PPAR-gamma[8], a receptor that can increase insulin sensitivity, which in turn helps in diabetes management. With such benefits, you can use CBD to manage your diabetic symptoms, especially chronic diabetic neuropathy. 

How to choose the best CBD? 

When shopping for CBD products, you may get confused with all the terms such as full spectrum CBD, hemp-derived CBD, and whatnot. Moreover, you may see that most of the CBD products are not approved by the Food and Drug Administration. But, it isn’t a red flag to bother about.

Because, the FDA has approved only one CBD-containing drug, known as Epidiolex. 

So, you don’t have to worry about the absence of an FDA-approved label. However, make sure you buy from the reputed sellers with a positive reputation. Coming to how you can buy and use different types of CBD products, here is a brief guide:

  • CBD Oil: It can be taken in pure oil form, a capsule, or by mixing it in smoothies, coffee, or other drinks. 
  • CBD Gummies: You can simply take a gummy into your mouth, chew it for a couple of minutes, and then swallow. CBD gummies can also be added as toppings for different food items. 
  • CBD Creams: Make sure that your skin is dry, where you are going to apply the CBD cream. Then, take some cream and gently massage it onto your skin. You can apply it 5 to 6 times a day, depending on your needs. 

Benefits of using CBD

Other than treating neuropathy, CBD also carries a lot of other benefits. With more studies being done, we are slowly getting to know how therapeutic CBD is. Anyhow, let us talk about the most prominent benefits of using CBD:

  • Can reduce anxiety, depression, and several other mental health issues.
  • Helps in treating seizures. Studies have shown that CBD can help manage Epilepsy.
  • According to the National Cancer Institute, Cannabis can also subdue cancer symptoms.
  • CBD is also known to alleviate acne intensity, making it an effective anti-acne agent. 
  • CBD also promotes heart health by managing high blood pressure[9].


While using any product related to health and wellness, you need to be a bit cautious. Do not start using a CBD product without consulting a doctor. You should discuss it with your doctor, and also ask him for the right dosages. Especially, if you are a pregnant woman or someone diagnosed with liver diseases or Parkinson’s, you might want to first take medical advice from a qualified physician. 

Potential Side Effects

Cannabis does carry some side effects with it. However, not everyone that takes it will experience these. It depends on your body condition, dosage, and a few other factors. Anyhow, here are a few potential side effects you may have to know:

  • Dry mouth
  • Reduced appetite
  • Diarrhea 
  • Fatigue
  • Drowsiness
  • Nausea

Final Thought

Diabetic nerve pain can wreak havoc in your life, especially when you do not treat it with certain medications that are effective. Cannabis is one such medication that works excellently against chronic pain in the legs and feet. CBD not only regulates inflammation but also subdues pain caused by your diabetes. Additionally, it also offers a wide range of benefits that can help you lead a healthy life. 

+ 9 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. ‌Wallace, M.S., Marcotte, T.D., Umlauf, A., Gouaux, B. and Atkinson, J.H. (2015). Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. The Journal of Pain, [online] 16(7), pp.616–627. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152762/ [Accessed 22 Jun. 2021].
  2. ‌Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S.-R., Willenbring, D., Guan, Y., Pan, H.-L., Ren, K., Xu, Y. and Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, [online] 209(6), pp.1121–1134. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371734/ [Accessed 22 Jun. 2021].
  3. ‌Tsuji, F. and Aono, H. (2012). Role of Transient Receptor Potential Vanilloid 1 in Inflammation and Autoimmune Diseases. Pharmaceuticals, [online] 5(8), pp.837–852. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763671/ [Accessed 22 Jun. 2021].
  4. ‌Szekely, Y., Ingbir, M., Bentur, O.S., Hochner, O. and Porat, R. (2020). Natural cannabinoids suppress the cytokine storm in sepsis-like in vitro model. European Cytokine Network, [online] 31(2), pp.50–58. Available at: https://pubmed.ncbi.nlm.nih.gov/32933892/ [Accessed 22 Jun. 2021].
  5. ‌Atalay, S., Jarocka-Karpowicz, I. and Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, [online] 9(1), p.21. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023045/ [Accessed 22 Jun. 2021].
  6. ‌Shannon, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal, [online] 23. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/ [Accessed 22 Jun. 2021].
  7. ‌Weiss, L., Zeira, M., Reich, S., Har-Noy, M., Mechoulam, R., Slavin, S. and Gallily, R. (2006). Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity, [online] 39(2), pp.143–151. Available at: https://pubmed.ncbi.nlm.nih.gov/16698671/ [Accessed 22 Jun. 2021].
  8. ‌O’Sullivan, S.E. (2016). An update on PPAR activation by cannabinoids. British Journal of Pharmacology, [online] 173(12), pp.1899–1910. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882496/ [Accessed 22 Jun. 2021].
  9. Jadoon, K.A., Tan, G.D. and O’Sullivan, S.E. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight, [online] 2(12). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/ [Accessed 22 Jun. 2021].
Lakshmi Vemuri

Medically reviewed by:

Kimberly Langdon

Lakshmi Vemuri holds a bachelor’s degree in Dentistry. She is also a published author of several Food and Wellness books. Lakshmi has a profound interest in alternative medicines, various forms of physical exercise, mental health, diets, and new inventions in medical sciences. Besides being a dentist, Lakshmi is passionate about gardening and is an environmental enthusiast

Medically reviewed by:

Kimberly Langdon

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