08:17pm Friday 06 December 2019

Dopaminergic Neurons Derived from Induced Pluripotent Stem Cells in Non-human Primate Model

New Rochelle, NY —Researchers have demonstrated the ability to generate dopaminergic neurons in the laboratory from induced pluripotent stem cells (iPSCs) derived from fibroblast cells of adult marmoset monkeys. This new study, documenting the iPSCs’ pluripotent properties and the potential for using this animal model to develop regenerative medicine approaches for dopamine-related disorders such as Parkinson’s disease, is published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website until September 8, 2017.

Marina Emborg, MD, PhD and colleagues from University of Wisconsin-Madison coauthored the article entitled “Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts.” The researchers reported that the marmoset fibroblast-derived iPSCs could differentiate into all three embryonic cell lineages: mesoderm, ectoderm, and endoderm. When stimulated to pattern themselves as neurons, the iPSCs expressed genes and other biomarkers consistent with a dopaminergic phenotype.

“This important study advances the marmoset as a model for Parkinson’s disease, for the first time deriving a line from the adult marmoset,” says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

Research reported in this publication was supported by the National Institutes of Health under Award Numbers R24OD019803, P51OD011106, UL1TR000427, and T32GM750738. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.



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