BOSTON — Caffeine could be related to an inverse association between basal cell carcinoma risk and consumption of coffee, a study found.
The prospective study, presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011, examined the risks of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma in connection with coffee consumption and found a decreased risk for BCC only.
“Given the nearly 1 million new cases of BCC diagnosed each year in the United States, daily dietary factors with even small protective effects may have great public health impact,” said researcher Fengju Song, Ph.D., a postdoctoral fellow in the department of dermatology at Brigham and Women’s Hospital and Harvard Medical School. “Our study indicates that coffee consumption may be an important option to help prevent BCC.”
Data were taken from the Nurses’ Health Study (Brigham and Women’s Hospital) and the Health Professionals Follow-Up Study (Harvard School of Public Health). In the Nurses’ Health Study, 72,921 participants were followed from June 1984 to June 2008. In the Health Professionals Follow-Up Study, 39,976 participants were followed from June 1986 to June 2008.
The researchers reported 25,480 incident skin cancer cases. Of those, 22,786 were BCC, 1,953 were SCC, and 741 were melanoma.
Song and colleagues reported that women who consumed more than three cups of coffee per day had a 20 percent reduction in risk for BCC, and men who consumed more than three cups per day had a nine percent risk reduction compared with people who consumed less than one cup per month.
The amount of coffee consumption was inversely associated with BCC risk. Those in the highest quintile had the lowest risk, with an 18 percent reduction for women and a 13 percent reduction for men.
Song and colleagues were surprised by the inverse connection in BCC cases only. Animal studies have suggested an association between coffee intake and skin cancer risk, but epidemiologic studies have not conclusively shown the same results, they said.
“Mouse studies have shown that oral or topical caffeine promotes elimination of UV-damaged keratinocytes via apoptosis (programmed cell death) and markedly reduces subsequent SCC development,” Song said. “However, in our cohort analysis, we did not find any inverse association between coffee consumption and the risk for SCC.”
Song said that additional studies specifically addressing the association between coffee consumption and BCC and the mechanism behind this association are warranted.
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, the AACR is the world’s oldest and largest professional organization dedicated to advancing cancer research. The membership includes 33,000 laboratory, translational and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 90 other countries. The AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants, research fellowships and career development awards to young investigators, and it also funds cutting-edge research projects conducted by senior researchers. The AACR has numerous fruitful collaborations with organizations and foundations in the U.S. and abroad, and functions as the Scientific Partner of Stand Up To Cancer, a charitable initiative that supports groundbreaking research aimed at getting new cancer treatments to patients in an accelerated time frame. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment and patient care, and Educational Workshops are held for the training of young cancer investigators. The AACR publishes seven major peer-reviewed journals: Cancer Discovery; Cancer Research; Clinical Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Prevention Research. In 2010, AACR journals received 20 percent of the total number of citations given to oncology journals. The AACR also publishes Cancer Today, a magazine for cancer patients, survivors and their caregivers, which provides practical knowledge and new hope for cancer survivors. A major goal of the AACR is to educate the general public and policymakers about the value of cancer research in improving public health, the vital importance of increases in sustained funding for cancer research and biomedical science, and the need for national policies that foster innovation and the acceleration of progress against the 200 diseases we call cancer.
In Boston, Oct. 22-25, 2011: