01:21am Friday 22 September 2017

Researchers Report Novel Way to Enhance Immunity Against Cancer

Charles Dimitroff

L to R: Jenna Geddes (seated), Erika Yazawa, Matthew Opperman, Dr. Filiberto Cedeno-Laurent, Dr. Steve Barthel, Dr. Charles Dimitroff (seated)

 In their recent report, published in The Journal of Dermatology, Dr. Dimitroff and colleagues use a well-characterized fluorinated analog of glucosamine (4-F-GlcNAc) to show for the first time that lowering the biosynthesis of certain carbohydrates that decorate the cell surface of effector immune cells, can dramatically boost their capacity to fight cancer.

Accordingly, this report highlights the modulation of immune responses established by Galectin-1 (Gal-1), a carbohydrate-binding protein that promotes evasion of immune responses, favoring tumor growth and metastasis. Eliminating Gal-1-mediated binding to immune cells resulted in elevations of pro-inflammatory T cell subsets, and remarkably, translated

Charles Dimitroff

Dr. Steve Barthel and Erika Yazawa

into negligible tumor growth. This research was funded by grants from the National Cancer Institute and the National Center for Complementary and Alternative Medicine, of the National Institutes of Health.


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