10:51am Friday 24 January 2020

Targeted therapy using sound-waves offers ‘male lumpectomy’ for prostate cancer

The study, funded by the Medical Research Council (MRC), is the first to use an experimental treatment known as HIFU (high-intensity focused ultrasound) to treat areas of cancer just a few millimetres in size (focal therapy). Focal therapy is similar in principle to the ‘lumpectomy’ operation commonly used as an alternative to a full mastectomy in breast cancer.

The results, published in Lancet Oncology, show that 12 months after treatment, none of the 41 men in the trial had incontinence of urine and just 1 in 10 suffered from poor erections – both common side effects of conventional treatment. The majority of men (95 per cent) were also cancer-free after a year.

Dr Hashim Ahmed, who led the study at University College London Hospitals NHS Foundation Trust (UCLH) and UCL (University College London), said:

“Our results are very encouraging. We’re optimistic that men diagnosed with prostate cancer may soon be able to undergo a day case surgical procedure, which can be safely repeated once or twice, to treat their condition with very few side-effects. That could mean a significant improvement in their quality of life.

“This study provides the proof-of-concept we need to develop a much larger trial to look at whether focal therapy is as effective as the current standard treatment in protecting the health of the men treated for prostate cancer in the medium and long term.”

Prostate cancer is the commonest cancer in men. In the UK, more than 37,000 men are diagnosed each year and the condition leads to approximately 10,000 deaths. However, men with prostate cancer can live for years without their disease getting worse and many are faced with a difficult decision between therapy that may lead to side effects and active surveillance of their condition. Research efforts have therefore centred around reducing the impact of treatment on quality of life.

The standard therapy currently involves treating the whole prostate, either with radiotherapy or surgery (removing it completely). Both cause damage to the surrounding healthy tissue and can lead to substantial side effects such as urinary incontinence requiring one or more pads a day (5-25 per cent), erections insufficient for sexual intercourse (30-70 per cent) and rectal problems (diarrhoea, bleeding, pain; 5-10 per cent).

Men who undergo traditional treatment have a 50 per cent chance of achieving the so-called trifecta status – the ‘perfect outcome’ with no urine leak, good erections and cancer control at 12 months after surgery or radiotherapy. In this study, the researchers showed that after focal therapy men have a 9 in 10 chance of achieving the trifecta outcome at 12 months.

The researchers previously used HIFU to treat the entire half of the prostate where the cancer was situated. That study also showed similar reduction in side-effects and encouraging early cancer control. In this study, they wanted to see if they could reduce damage to healthy tissue even further by treating only the specific cancer sites.

They used two highly sensitive diagnostic techniques – MRI and mapping biopsies – to enable them to pinpoint the exact location of the cancer lesions(s), something which is not possible with standard diagnostic tests (transrectal biopsy).

The researchers then targeted these areas with the HIFU device. HIFU focuses high frequency sound waves onto an area the size of a grain of rice. The sound waves cause the tissue to vibrate and heat to about 80 degrees, killing the cells in the target area. The procedure is performed in hospital under general anaesthetic and most patients are back home within 24 hours.

The research programme is led by Professor Mark Emberton, of UCL and UCLH. He said:

“Focal therapy offers harm reduction – it is a strategy that attempts to redress the balance of harms and benefits by offering men who place high utility on genito-urinary function an alternative to standard care. In fact, the concept is not new – tissue preserving strategies have been used successfully in all other solid organ cancers such as breast cancer by offering women a lumpectomy rather than mastectomy.”

Professor Gillies McKenna, director of the MRC/Cancer Research UK Gray Institute for Radiation Oncology and Biology, said:

“Clinical trials, like this one supported by the MRC, are a fantastic tool for telling us whether experimental new treatments are likely to be effective in the clinic. If these promising results can be confirmed in a randomised controlled trial, focal therapy could soon become a reasonable treatment choice for prostate cancer alongside other proven effective therapies.”

The research was funded by the MRC, the Pelican Cancer Foundation and St Peter’s Trust.

Notes to editors

Dr Hashim Ahmed and Professor Mark Emberton are available for interview. Case studies are also available on request. Please contact:

Hannah Isom

Senior press officer, Medical Research Council

T: 0207 395 2345 (out of hours: 07818 428 297)

E: press.office@headoffice.mrc.ac.uk


  • 1. The paper, ‘Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study’, by Ahmed et al, is published in Lancet Oncology. A copy is available on request.
  • 2. For almost 100 years the Medical Research Council has improved the health of people in the UK and around the world by supporting the highest quality science. The MRC invests in world-class scientists. It has produced 29 Nobel Prize winners and sustains a flourishing environment for internationally recognised research. The MRC focuses on making an impact and provides the financial muscle and scientific expertise behind medical breakthroughs, including one of the first antibiotics penicillin, the structure of DNA and the lethal link between smoking and cancer. Today MRC funded scientists tackle research into the major health challenges of the 21st century. www.mrc.ac.uk
  • 3. The Pelican Cancer Foundation is a recognised leading world authority for precision surgery for colorectal cancers and tumours of the liver. Pelican’s advanced surgical technique and imaging of bowel cancer provides greatly improved outcomes for patients.  The aim of Pelican Cancer Foundation is to help lower bowel, liver, prostate and bladder cancer patients survive their diagnosis of cancer for longer, and to have a good quality of life after cancer treatment. Pelican Cancer Foundation achieves its aim by supporting medical education and medical research. The Foundation runs workshops, courses, meetings and national training programmes for cancer specialists. It also funds a portfolio of research projects that widen the understanding of innovative diagnostics and surgical treatments for below-the-belt cancers. Pelican Cancer Foundation is based at Basingstoke and North Hampshire Foundation Trust and works closely with the hospital’s multi-disciplinary cancer specialists. Pelican directly supports the work of the colorectal, hepatobiliary and urology teams at the hospital. Website www.pelicancancer.org Charity number 1019311.
  • 4. St Peter’s Trust for Kidney, Bladder & Prostate Research is a small charity which has made a significant contribution in this country to understanding diseases and developing novel methods of treatment. It is unique in the UK in funding medical research on disorders that affect any part of the urinary tract. The objective of the Trust is to improve the methods of prevention, diagnosis, treatment and cure, of diseases affecting the urinary tract, including prostate cancer. It does so by providing pump-priming grants for innovative research, to establish the potential value of an idea, with the aim of encouraging the major medical research charities to provide longer term funding.   It also aims to support the training of young researchers working in this field, and enable researchers to take full advantage of the opportunities they have for major medical advances through collaboration between the world class clinical and scientific departments at UCL.
  • 5. University College London. Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. UCL is among the world’s top universities, as reflected by performance in a range of international rankings and tables. UCL currently has over 13,000 undergraduate and 9,000 postgraduate students. Its annual income is over £700 million. www.ucl.ac.uk
  • 6. University College Hospital. University College London Hospitals NHS Foundation Trust (UCLH), situated in the West End of London, is one of the largest NHS trusts in the United Kingdom and provides first-class acute and specialist services. The new state-of-the-art University College Hospital which opened in 2005, is the focal point of the trust alongside six cutting-edge specialist hospitals. The Trust is committed to research and development and forms part of UCL Partners which in March 2009 was officially designated as one of the UK’s first academic health science centres by the Department of Health. UCLH works closely with UCL translating research into treatments for patients. www.uclh.nhs.uk

  • Share on:

    MORE FROM Cancers

    Health news